Care gap: Hospital readmission rate for younger women is higher than for younger men after a heart attack

In a new studyopens in new tab/window of younger heart attack victims in Ontario, Canada, researchers found that the healthcare system delivers high quality care for younger heart attack survivors; however, there are still disparities between men and women. Cardiovascular and all-cause hospital readmission rates are higher in young women than young men. This underscores the need for ongoing efforts to improve prevention strategies, as risk factors for heart disease in young women continue to rise. Their findings appear in the Canadian Journal of Cardiologyopens in new tab/window published by Elsevier.

Despite improvements in the management and outcomes of patients with ischemic heart disease, a large number of women are hospitalized with acute myocardial infarction (AMI) annually. Several prior studies have found that women have worse outcomes compared to men after experiencing a heart attack. Young women were found to be at particularly high risk, with much higher mortality rates than young men, and worse outcomes even when compared with older women. As a result, vigorous efforts to address these treatment disparities were aimed at the public and healthcare providers.

“Many care gaps are closing for younger women with AMI in Ontario, but readmission rates remain higher than for younger men,” explained lead investigator Mina Madan, MD, MHS, Schulich Heart Centre, Sunnybrook Health Sciences Centre, and Department of Medicine, University of Toronto, Toronto, ON, Canada.

Using ICES data, investigators studied clinical outcomes in 38,071 heart attack survivors aged 18 to 55 years who were hospitalized in Ontario, Canada, between April 1, 2009 and March 31, 2019 with a diagnosis of AMI. Of these, 8,077 (21.2%) were women. They compared trends in cardiac risk factors, angiographic findings, and revascularization rates in men and women and studied their outcomes during the first year after the heart attack.

The researchers found that younger women hospitalized with an AMI had a significantly higher prevalence of cardiac risk factors and comorbidities compared to younger men with AMI. Notably, there was a steady increase in the prevalence of diabetes in women over time. Close to 25% had diabetes in 2009 compared to close to 35% in 2018, which was much higher than among men, whose rates of diabetes increased by just 4%, from 18% to 22%, over the same time period. By 2018, more than one in three young women with AMI had diabetes, almost half had hypertension and dyslipidemia, and more than two in five were current smokers.

Although earlier studies found that women were less frequently referred for coronary angiography to evaluate for blockages of the blood supply to the heart, by 2018 the use of coronary angiography was largely universal for both sexes. Young women were less frequently referred for angioplasty or bypass surgery compared to young men, which could be explained by a greater prevalence of normal coronary arteries and non-obstructive coronary artery disease observed during angiography among women.

Over the study period, adjusted mortality rates for younger men and women after hospitalization for heart attack were similar. However, rehospitalization rates for adverse cardiovascular events and all-cause readmission rates were significantly higher for women (25.8% for women vs. 21.1% for men).

“This may reflect the higher risk profile we observed among younger women in our study compared with younger men or support the notion that younger women may benefit from earlier follow-up care and better support networks that could reduce the need for readmissions soon after discharge,” said Dr. Madan.

In an accompanying editorialopens in new tab/window, lead author Karin H. Humphries, MBA, DSc, University of British Columbia, Faculty of Medicine, Vancouver, BC, Canada, comments, “This important analysis presents us with both good news and bad news. While it provides evidence that the sex differences in AMI are diminishing, there is also an urgent need to understand what is driving the higher readmission rates in females. Is this due to unrecognized depression, less use of evidence-based medication post AMI, or delays in access to care? More focus on these areas of investigation is clearly needed.”

“There is definitely room to do better,” Dr. Madan agrees, “by taking steps that could reduce early readmission rates for younger women and renewed public education initiatives to raise awareness about the importance of diet, exercise and healthy lifestyle choices to avoid developing cardiovascular disease.”

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Notes for editors

The article is “Clinical Outcomes in Younger Women Hospitalized With an Acute Myocardial Infarction: A Contemporary Population-Level Analysis,” by Mina Madan, MD, MHS, Feng Qiu, MSc, Maneesh Sud, MD, Michelle M. Graham, MD, Jacqueline Saw, MD, Harindra Wijeysundera, MD, PhD, Gynter Kotrri, MD, Peter C. Austin, PhD, and Dennis T. Ko, MD, MSc (https://doi.org/10.1016/j.cjca.2022.06.023opens in new tab/window).

This study was funded in part by an Innovation in Quality Award from the Division of Cardiology, University of Toronto, Toronto, Ontario, Canada, and in part by a Foundation Grant (FDN-154333) from the Canadian Institutes of Health Research. Dr. Madan is supported by the Heart and Stroke Foundation Polo Chair in Cardiology at the University of Toronto. Dr. Austin is supported by a Mid-Career Award from the Heart and Stroke Foundation. Dr. Ko is supported by the Jack Tu Chair of Cardiovascular Outcomes Research.

The editorial is “Sex Differences in Acute Myocardial Infarction: Good News and Bad News,” by Karin H. Humphries, MBA, DSc, Colleen M. Norris, RN, PhD, and Louise Pilote, MD, MPH, PhD (https://doi.org/10.1016/j.cjca.2022.08.227opens in new tab/window).

Both articles appear online ahead of the Canadian Journal of Cardiology, volume 38 issue 11 (November 2022) published by Elsevier.

Full text of the articles is available to credentialed journalists upon request. Contact Eileen Leahy at +1 732 238 3628or [email protected]opens in new tab/window to obtain copies. Journalists wishing to speak to the study’s authors should contact Katherine Nazimek at [email protected]opens in new tab/window. To reach the editorial’s authors for comment, contact Karin H. Humphries, MBA, DSc, at [email protected]opens in new tab/window.

About the Canadian Journal of Cardiology

The Canadian Journal of Cardiologyopens in new tab/window is the official journal of the Canadian Cardiovascular Societyopens in new tab/window. It is a vehicle for the international dissemination of new knowledge in cardiology and cardiovascular science, particularly serving as a major venue for the results of Canadian cardiovascular research and Society guidelines. The journal publishes original reports of clinical and basic research relevant to cardiovascular medicine as well as editorials, review articles, case reports, and papers on health outcomes, policy research, ethics, medical history, and political issues affecting practice. 

About the Editor-in-Chief

Editor-in-Chief Stanley Nattel, MD, is Paul-David Chair in Cardiovascular Electrophysiology and Professor of Medicine at the University of Montreal and Director of the Electrophysiology Research Program at the Montreal Heart Institute Research Center.

About the Canadian Cardiovascular Society (CCS)

The CCSopens in new tab/window is the national voice for cardiovascular clinicians and scientists, representing more than 2,300 cardiologists, cardiac surgeons and other heart health specialists across Canada. We advance heart health for all by setting standards for excellence in heart health and care, building the knowledge and expertise of the heart team, and influencing policy and advocating for the heart health of all Canadians. For further information on the CCS visit https://ccs.ca/opens in new tab/window.

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