Illicit drug use is involved in nearly one in three sudden cardiac deaths in young adults

Approximately one-third of young adults in Victoria, Australia, who experienced sudden cardiac deaths (SCDs) outside of a hospital setting from April 2019 to April 2021 used illegal drugs prior to their fatal events, reports a new study opens in new tab/window in Heart Rhythm opens in new tab/window, the official journal of the Heart Rhythm Society, the Cardiac Electrophysiology Society, and the Pediatric & Congenital Electrophysiology Society, published by Elsevier. The analysis of data on substance abuse, revealed through positive toxicology reports and patient histories and recorded in one of the world’s largest and most comprehensive SCD registries, shows higher levels of illicit drugs than is typical for that population, as well as a greater prevalence of multiple substance use.

The investigators analyzed data from a statewide registry on patients aged 18–50 years who experienced out-of-hospital SCD between April 2019 and April 2021 in Victoria, Australia (population 6.5 million). Toxicology assessment results were available for nearly all patients, 32.5% of which were positive for drug use. Previous estimates of drug use in Australia had ranged from approximately 16% overall to 19% for those aged 14-49.

Lead investigator Elizabeth D. Paratz, MBBS, PhD, FRACP, Baker Heart and Diabetes Institute; noted, “As clinicians in Melbourne, we frequently see complications of illicit drug use in young people. We noticed a consistent trend of illicit drugs involved in our registry’s young SCD cohort and were very keen to tease this out further. We found the prevalence of illicit drug use in young SCD patients was astonishingly high at almost one in three cases and exceeds reported rates in the young population.

The study focused on patients for whom a cardiovascular cause of death was identified and does not include those who died suddenly of illicit drug overdoses, i.e., the illicit drugs were thought to be incidental. These patients were more likely to be male, smokers, and excessive alcohol drinkers, and had a psychiatric diagnosis, lower body mass index, and lower rates of hypertension. Their deaths commonly occurred while they were sedentary or sleeping. While cannabis was the most common illicit drug identified, others included cocaine, amphetamines, heroin, and novel/psychoactive substances; more than one substance was frequently involved.

Dr. Paratz commented, “We were surprised by the very high rates of illicit drugs prevalent in the toxicological results of this group as compared to the overall population. Our findings raise the question: Is substance abuse underestimated or does it lead to a higher rate of cardiovascular pathology that results in SCD? We know that some young people may have a genetic predisposition for sudden death or developing coronary disease, but drug use may interact with this tendency to accelerate poor outcomes.”

An editorial opens in new tab/window accompanying the study by Kristina H. Haugaa, MD, PhD, and Anna I. Castrini, MD, ProCardio Center for Innovation, Department of Cardiology, Oslo University Hospital, Rikshospitalet, and University of Oslo, contextualizes the findings in terms of the need to better understand how drug use contributes to cardiac disease in adults under 50 -- which is critical since it is potentially a reversible risk factor.

Dr. Haugaa and Dr. Castrini explained, “Illicit drugs have well known acute and chronic effects on the cardiovascular system and can act as arrhythmic triggers. Amphetamine and cocaine activate the sympathetic system and induce tachycardia and vasoconstriction, resulting in ischemia and potentially myocardial infarct. These drugs can trigger SCD in younger patients with predisposing diseases including congenital or inherited cardiac diseases, premature coronary disease, and myocarditis. However, still up to 30% of deaths remain unexplained after autopsy. Even when the predisposing disease has been identified, we are often left with a major question about which transient event triggered the cardiac death.”

SCDs represent 50% of all cardiovascular deaths and occur unexpectedly in people without prior history of cardiac disease or a known predisposition for it.

Dr. Haugaaadded, “We believe that the paper from Trytell et al. will enlighten further research on the topic. The study underlines the importance of requiring autopsy and toxicology analysis, especially in young individuals, and may help to explain some of the unexplained.”

---

Notes for editors

The article is “Prevalence of illicit drug use in young patients with sudden cardiac death,”byAdam Trytell, MBBS, Michael Osekowski, MBBS, Dominica Zentner, MBBS, PhD, FRACP, Ziad Nehme, PhD, Paul James, MBChB, PhD, FRACP, Andreas Pflaumer, MD, FRACP, FHRS, Chris Semsarian, MBBS, PhD, FRACP, FHRS, Jodie Ingles, PhD, Dion Stub, MBBS, PhD, FRACP, Andre La Gerche, MBBS, PhD, FRACP, and Elizabeth D. Paratz, MBBS, PhD, FRACP (https://doi.org/10.1016/j.hrthm.2023.06.004 opens in new tab/window).

The editorial is “Sudden cardiac death in the young—Can illicit drug use explain the unexplained?”by Kristina H. Haugaa, MD, PhD, and Anna I. Castrini, MD (https://doi.org/10.1016/j.hrthm.2023.06.014 opens in new tab/window).

The articles appear online in advance of Heart Rhythm, volume 20, Issue 10 (October 2023) published by Elsevier.

Full text of the articles is available to credentialed journalists upon request; contact Jane Grochowski at +1 406 542 8397 or [email protected] opens in new tab/window. Journalists who wish to interview the study authors should contactTracey Ellis, Head of Public Affairs, Baker Heart and Diabetes Institute, at +61 433 781 972 or [email protected] opens in new tab/window. Kristina H. Haugaa, MD, PhD, may be reached for comment at [email protected] opens in new tab/window.

About Heart Rhythm

Heart Rhythm opens in new tab/window, the official Journal of the Heart Rhythm Society opens in new tab/window, the Cardiac Electrophysiology Society opens in new tab/window, and the Pediatric & Congenital Electrophysiology Society opens in new tab/window, is a unique journal for fundamental discovery and clinical applicability. It integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community. www.heartrhythmjournal.com opens in new tab/window

About the Heart Rhythm Society

The Heart Rhythm Society opens in new tab/window is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal healthcare policies and standards. The Heart Rhythm Society is the preeminent professional group representing more than 8,000 specialists in cardiac pacing and electrophysiology from more than 94 countries. www.HRSonline.org opens in new tab/window

About Electrophysiology

Electrophysiology is a branch of cardiology focusing on the electrical system of the heart. Electrophysiologists specialize in the diagnosis of cardiac rhythm disorders and their treatment, including the implantation of cardiac rhythm management devices (pacemakers, defibrillators, etc.).

About Elsevier

As a global leader in scientific information and analytics, Elsevier helps researchers and healthcare professionals advance science and improve health outcomes for the benefit of society. We do this by facilitating insights and critical decision-making with innovative solutions based on trusted, evidence-based content and advanced AI-enabled digital technologies.

We have supported the work of our research and healthcare communities for more than 140 years. Our 9,500 employees around the world, including 2,500 technologists, are dedicated to supporting researchers, librarians, academic leaders, funders, governments, R&D-intensive companies, doctors, nurses, future healthcare professionals and educators in their critical work. Our 2,900 scientific journals and iconic reference books include the foremost titles in their fields, including Cell Press, The Lancet and Gray’s Anatomy.

Together with the Elsevier Foundation opens in new tab/window, we work in partnership with the communities we serve to advance inclusion and diversity in science, research and healthcare in developing countries and around the world.

Elsevier is part of RELX opens in new tab/window, a global provider of information-based analytics and decision tools for professional and business customers. For more information on our work, digital solutions and content, visit www.elsevier.com.