Noted experts present detailed evidence on the impact of environmental issues on cardiovascular health

There is already robust evidence that people living with cardiovascular disease are disproportionately affected by poor air quality and extreme temperatures, in large part due to climate change, the greatest threat to human health of the 21st century.In this special theme issue opens in new tab/window of the Canadian Journal of Cardiology opens in new tab/window, published by Elsevier, noted experts comprehensively review how climate change occurs and increases the risk of cardiovascular disease and provide practical tips on how to become a climate-smart cardiovascular healthcare provider.

Not long ago, climate change was a fringe topic deemed only to affect rare species and ignored by many. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 opens in new tab/window estimated that nine million people died prematurely because of air pollution in 2019. Nearly 62% of these deaths were related to cardiovascular diseases, highlighting the fact that climate change is not only a general healthcare issue, but also a major cardiovascular health issue.

This issue of the Canadian Journal of Cardiology is guest-edited by Sadeer Al-Kindi, MD, Houston Methodist DeBakey Heart and Vascular Center; Matthew Bennett, MD, FRCPC, University of British Columbia; Daniel Gagnon, PhD, Montreal Heart Institute; Sanjay Rajagopalan, MD, FACC, FAHA, Harrington Heart and Vascular Institute; and François Reeves, MD, FRCPC, University of Montreal.

The Guest Editors explain: "The health effects of heat extremes and poor air quality notably drew attention recently because of the 2021 heat dome that resulted in 619 heat-related deaths in British Columbia, Canada, the European summer of 2022 that was the hottest on record and caused an estimated 61,672 heat-related deaths, and the wildfires in Québec, Canada, that caused poor air quality across vast areas of Northeastern America during the summer of 2023. Within this context, it has never been more relevant to understand how environmental influences affect cardiovascular health to mitigate their effects."

In addition to extreme weather and air pollution being associated with cardiovascular events, it is increasingly recognized that the comprehensive lifetime exposure of individuals and populations to their surrounding environment (the exposome) is closely interlinked to cardiovascular health and wellbeing. Issam Motairek, MD, Case Western Reserve University School of Medicine, and colleagues review the relationship between the exposome and cardiovascular health, highlighting the epidemiological and mechanistic evidence of environmental exposures on cardiovascular disease. This review also reinforces the importance of minimizing long-term pollutant exposure for the prevention of cardiovascular disease.

^{Caption: Features of the exposome associated with cardiovascular health (Credit Canadian Journal of Cardiology, created with BioRender.com).}

Aerial nano-aggressors (air pollution), food nano-aggressors (hyperprocessed food), the level of greening, and an environment encouraging (or not) physical activity are major environmental determinants of heart health. François Reeves, MD, FRCPC, and Brian J. Potter, MDCM, SM, FRCPC, both of the University of Montreal, propose a cardio-environmental model for cardiovascular risk assessment of easily evaluated factors by asking: (1) who is my patient? (family history, ethnicity, traditional risk factors, body mass index, and comorbidities); (2) what does my patient do? (eating habits, smoking, drugs, physical activity); and (3) where does my patient live? (air quality, food quality, urban environment).

Caption: Cardio-environmental model of cardiovascular disease risk. The authors illustrate how air pollution, hyperprocessed foods, the amount of green space, and population activity levels are now considered the four major environmental determinants of cardiovascular health and provide a framework for how these considerations might be incorporated into clinical risk assessment (Credit Canadian Journal of Cardiology).

A review by Barrak Alahmad, MD, PhD, Harvard T.H. Chan School of Public Health, and colleagues shows that climate change and air pollution worsen each other leading to several ecosystem-mediated impacts. They highlight how increases in hot climates as a result of climate change have increased the risk of major air pollution events such as severe wildfires and dust storms and that altered atmospheric chemistry and changing patterns of weather conditions can promote the formation and accumulation of air pollutants, a phenomenon known as the climate penalty.

Extreme heat events, in which temperature and/or humidity are sufficiently elevated to generate health impacts at a population level, are an important consequence of the accelerating climate crisis.Daniel Gagnon, PhD, and colleagues describe how the human body interacts with a hot environment during physical activity, summarize current hot weather guidelines for physical activity, and conclude with practical strategies to encourage safe physical activity in hot weather.

David Kaiser MD, MSc, McGill University, and colleagues point out that cardiovascular clinicians and researchers are uniquely placed to help prevent heatwave mortality by identifying patients who are most at risk and using education, referrals, and advocacy to contribute to public health interventions.

Hypertension is responsible for nearly nine million deaths worldwide annually; environmental pollution increases the incidence of hypertension and exacerbates its severity. Environmental aggressors include the adverse vascular effects of air pollution, lack of green spaces, increased risk of infection, lack of physical activity, temperature effects, noise pollution, disturbance of circadian rhythm, and economic disparities such as limited access to healthcare. Francisco J. Rios, PhD, McGill University Health Centre, and colleagues highlight their crucial impact and how these determinants influence diverse communities. They also address opportunities and challenges for new research to address knowledge gaps in our understanding of the molecular mechanisms through which environmental factors influence development of hypertension and associated cardiovascular disease.

Adverse air quality increases the risk of many cardiovascular diseases including atherosclerosis and, as a result, the incidence of myocardial infarction, stroke, and cardiovascular death. In addition, acute and chronic increases in air pollution increase the risk of atrial and ventricular arrhythmias, heart failure incidence, and heart failure-related hospitalizations. A review by Matthew Bennett, MD,and colleagues discusses the association between both acute and chronic air pollution exposure and arrhythmia incidence, morbidity and mortality, and the purported pathophysiological mechanisms. They highlight several pathways mediating this association, including increases in inflammation, oxidative stress, mitochondrial and autonomic dysfunction, cardiac structural changes, and altered calcium, potassium, and sodium channel function.

Cavin K. Ward-Caviness, PhD, and Wayne E. Cascio, MD, both of the US Environmental Protection Agency, found substantial evidence linking air pollution exposure to heart failure incidence and related hospitalizations. They propose that further studies specifically to identify data gaps will greatly improve our knowledge of the susceptibility of individuals with heart failure and interventions to reduce risks.

The World Health Organization has reported that more than 1.6 million healthy life-years are lost yearly from traffic-related noise in western Europe. Thomas Münzel, MD, University Medical Center Mainz, and colleagues provide an overview of the “so-called” nonauditory cardiovascular health effects of noise, including acute and chronic ischemic heart disease, heart failure, arrhythmia, and stroke. They also provide evidence from translational human and experimental noise studies and discuss maneuvers to mitigate noise effectively.

Khalid Al-Thalji, MD, University of Toronto, and colleagues describe how to incorporate environmental cardiology into medical education to create climate-smart cardiovascular health care providers to minimize the cardiovascular effects of climate change in patients and the general population, improve awareness of these effects, and create climate change advocates within the cardiovascular community.

The Guest Editors comment: "Through the education of cardiovascular healthcare practitioners, trainees, the public, and policy makers regarding how and to what degree climate change increases the risk of cardiovascular disease, the impact of environmental factors on cardiovascular health can be minimized."

Aditya Khetan, MD, McMaster University, and Sadeer Al-Kindi, MD, Case Western Reserve University, explain how patients can adapt to environmental risk and, in particular, what recommendations should be given to high-risk patients during “bad air” days and during times of hot or cold temperatures.

The Guest Editors conclude: "The association between climate change and cardiovascular events is clear. Cardiovascular health practitioners, as healthcare leaders and educators, can play a leading role in minimizing the effect of environmental factors on cardiovascular health. Ongoing and future research will help manage the influence of environmental factors on cardiovascular health to thrive in a warmer planet."

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Notes for editors

Special theme issue

CJC Theme Issue: Environmental Determinants of Cardiovascular Disease Pathophysiology and Therapeutics

Guest editors: Sadeer Al-Kindi, MD, Houston Methodist DeBakey Heart and Vascular Center Matthew Bennett, MD, FRCPC, University of British Columbia Daniel Gagnon, PhD, Montreal Heart Institute Sanjay Rajagopalan, MD, FACC, FAHA, Harrington Heart and Vascular Institute François Reeves, MD, FRCPC, University of Montreal

The articles appear in the Canadian Journal of Cardiology, volume 39, issue 9 (September 2023) at https://www.onlinecjc.ca/issue/S0828-282X(23)X0010-5 opens in new tab/window, published by Elsevier. The articles are freely available for 30 days.

Full text of the articles is also available to credentialed journalists upon request. Contact Eileen Leahy at +1 732 238 3628or [email protected] opens in new tab/window to obtain copies. Journalists wishing to speak to the Guest Editors or authors should contact Sadeer Al-Kindi, MD, at [email protected] opens in new tab/window, Matthew Bennett, MD, FRCPC, at [email protected] opens in new tab/window, or François Reeves, MD, FRCPC, at [email protected] opens in new tab/window.

Of related interest, “Climate and Heart Health,” a Canadian Cardiovascular Society podcast, was posted on Cardio Connector at https://ccs.simplecast.com/episodes/climate-and-heart-health opens in new tab/window. A podcast featuring the Canadian Journal Cardiology September 2023 theme issue will be posted on Cardio Connector during the week of September 18.

About the Canadian Journal of Cardiology

The Canadian Journal of Cardiology opens in new tab/window is the official journal of the Canadian Cardiovascular Society opens in new tab/window. It is a vehicle for the international dissemination of new knowledge in cardiology and cardiovascular science, particularly serving as a major venue for the results of Canadian cardiovascular research and Society guidelines. The journal publishes original reports of clinical and basic research relevant to cardiovascular medicine as well as editorials, review articles, case reports, and papers on health outcomes, policy research, ethics, medical history, and political issues affecting practice. www.onlinecjc.ca opens in new tab/window

About the Editor-in-Chief

Editor-in-Chief Stanley Nattel, MD, is Paul-David Chair in Cardiovascular Electrophysiology and Professor of Medicine at the University of Montreal and Director of the Electrophysiology Research Program at the Montreal Heart Institute Research Center.

About the Canadian Cardiovascular Society (CCS)

The CCS opens in new tab/window is the national voice for cardiovascular clinicians and scientists, representing more than 2,300 cardiologists, cardiac surgeons and other heart health specialists across Canada. We advance heart health for all by setting standards for excellence in heart health and care, building the knowledge and expertise of the heart team, and influencing policy and advocating for the heart health of all Canadians. For further information on the CCS visit https://www.ccs.ca/en opens in new tab/window.

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