Endocrine Hypertension

About the Editors

Professor Joseph M. Pappachan MD, FRCP is a consultant endocrinologist at Lancashire Teaching Hospitals NHS Trust and an honorary professor at the Manchester Metropolitan University, UK. He is also a section editor (endocrinology & metabolism) to “Current Drug Safety” and associate editor to the “World Journal of Diabetes” and “Frontiers in Clinical Diabetes and Healthcare”. He has vast editing experience including editing journal special issues since 2010 and has authored more than 100 peer-reviewed articles in various medical journals and textbooks. He also has extensive academic collaboration across the globe and is a principal investigator in several ongoing clinical trials in endocrinology & metabolism. His research special interests include endocrine hypertension, neuroendocrinology, parathyroid disease, bone mineral metabolism, diabetic foot disease and diabesity. Dr. Cornelius James Fernandez MD, MRCP is a consultant endocrinologist at Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston, UK. He graduated from Kottayam Medical College, and underwent internal medicine postgraduate training from Coimbatore Medical College (India) with further specialist training in Endocrinology in the U.K. He is a review editor to “Frontiers in Clinical Diabetes and Healthcare” and scientific peer reviewer to several other medical journals. He has authored 35 peer reviewed scientific papers to date in different medical journals and actively involves in clinical research programs in his hospital. His research special interests include endocrine hypertension, diabetic foot disease and diabesity.

About this Book

Endocrine Hypertension: From Basic Science to Clinical Practice Edited by Joseph M. Pappachan and Cornelius James Fernandez

Endocrine hypertension is a term used to describe a group of endocrine pathologies that cause an elevation of blood pressure, estimated to account for up to 10% of all hypertension cases. Although common, this clinical condition is often overlooked, and patients are at risk of late diagnosis, delayed treatment, and detrimental health consequences.

Endocrine Hypertension: From Basic Science to Clinical Practice bridges the gap between scientists and practicing clinicians by providing a comprehensive overview to all forms of endocrine hypertension, covering epidemiological aspects, pathophysiology, clinical presentation, laboratory evaluation, and practical management aspects of endocrine hypertension.

This book is a great resource for endocrinologists, physicians, general practitioners, and researchers willing to understand the complex facets of endocrine hypertension.

Table of Contents and Author Information

1. Forward – Prof Ernesto Shiffrin C.M., MD, PhD, FRSC, FRCPC, FACP, Physician-in Chief, Sir Mortimer B. Davis-Jewish General Hospital, Director, Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research, Distinguished James McGill Professor and Associate Chair, Department of Medicine, McGill University, Editor in Chief - American Journal of Hypertension.

2. Chapter 1. Endocrine hypertension – an overview (Editorial chapter). Prof Joseph M Pappachan MD, FRCP, Department of Endocrinology & Metabolism, Lancashire Teaching Hospitals NHS Trust and Faculty of Science, Manchester Metropolitan University, UK; Dr. Cornelius J Fernandez MD, MRCP, Department of Endocrinology & Metabolism, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston, UK. (Authors & Editors).

3. Chapter 2. Catecholamines and blood pressure regulation: Dr. Cornelius J Fernandez MD, MRCP, Department of Endocrinology & Metabolism, Pilgrim Hospital, Boston, UK; Prof Fahmy WF Hanna MD, FRCP, Department of Diabetes and Endocrinology, University Hospitals of North Midlands NHS Trust & Centre for Health & Development, Staffordshire University, Stoke-on-Trent, UK; Prof Karel Pacak PhD, DSc & Dr. Matthew A Nazari MD, Section on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

4. Chapter 3. Adrenal Cortical Hormones and Blood Pressure Regulation: Dr. Anna Sanders PhD, FRCPath, Department of Clinical Biochemistry, Dudley Group NHS Foundation Trust, UK; Dr. Cornelius J Fernandez MD, MRCP, Department of Endocrinology & Metabolism, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston, UK. Prof Rousseau Gama MD, FRCPath, Department of Laboratory & Metabolic Medicine, The Royal Wolverhampton NHS Trust & the University of Wolverhampton, UK.

5. Chapter 4. Hypothalamic-Pituitary-Adrenal Axis and Blood Pressure Regulation. Prof Joseph M Pappachan MD, FRCP, Department of Endocrinology & Metabolism, Lancashire Teaching Hospitals NHS Trust and Faculty of Science, Manchester Metropolitan University, UK; Dr. Cornelius J Fernandez MD, MRCP, Department of Endocrinology & Metabolism, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston, UK; Prof Constantine Stratakis MD, PhD, Emeritus Professor & Former Scientific Director, National Institute of Health, USA, Human Genetics & Precision Medicine, IMMB, FORTH & ELPEN Research Institute, Greece.

6. Chapter 5. Renin-Angiotensin-Aldosterone System and blood pressure regulation. Prof Gino Seravalle MD, PhD, Cardiology Department, IRCCS Istituto Auxologico Italiano, and University Milano-Bicocca, Milano, Italy; Prof Guido Grassi MD, PhD, Clinica Medica, University of Milano-Bicocca, Milan, Italy.

7. Chapter 6. Monogenic Hypertension – an overview: Dr. Cornelius J Fernandez MD, MRCP, Department of Endocrinology & Metabolism, Pilgrim Hospital, Boston, UK; Prof Joseph M Pappachan MD, FRCP, Department of Endocrinology & Metabolism, Lancashire Teaching Hospitals NHS Trust and Faculty of Science, Manchester Metropolitan University, UK; Prof Ute I Scholl MD, PhD, Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Center of Functional Genomics, Germany.

8. Chapter 7. Primary Aldosteronism (Conn’s syndrome): Assoc Prof Filippo Ceccato MD, PhD; Dr. Irene Tizianel MD; Giacomo Voltan MD; & Prof Franco Mantero, MD, Endocrinology Unit,Department of Medicine DIMED, University Hospital of Padova, Universita Padova, Italy.

9. Chapter 8. Familial Hyperaldosteronism. Prof Joseph M Pappachan MD, FRCP, Department of Endocrinology & Metabolism, Lancashire Teaching Hospitals NHS Trust and Faculty of Science, Manchester Metropolitan University, UK; Dr. Cornelius J Fernandez MD, MRCP, Department of Endocrinology & Metabolism, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston, UK; Assoc Prof David S Geller MD, PHD, Department of Nephrology, West Haven VA Hospital, West Haven andYale University School of Medicine, New Haven, USA.

10. Chapter 9. Congenital Adrenal Hyperplasia and Hypertension. Dr. Busra Gurpinar Tosun, MD & Prof. Tulay Guran MD, Department of Pediatric Endocrinology & Diabetes, Marmara University School of Medicine, Istanbul, Turkey.

11. Chapter 10. Endocrine Hypertension: Discovering the Inherited Causes. Prof Farahnak Assadi MD, Rush University of Medical Center, Department of Pediatrics, Division of Nephrology, Chicago, IL, USA; Dr. Nakysa Hooman, MD, Aliasghar Clinical Research Development Center, Iran University of Medical Sciences, Department of Pediatric Nephrology, Tehran, Iran; Dr. Mojgan Mazaheri MD, Semnan University of Medical Sciences, Pediatric Nephrology, Iran; Assoc Prof Fatemeh Ghane Sharbaf MD, Department of pediatric Nephrology, Mashhad university of Medical sciences , Iran.

12. Chapter 11. Pheochromocytomas and Hypertension. Prof Iuri Goemann MD, PhD, & Prof Ana Luzia Maia MD, PhD, Universidade Federal Do Rio Grande Do Sul, Endocrinology, Porto Alegre, Brazil.

13. Chapter 12.Paragangliomas and hypertension: Prof Tomáš Zelinka MD, PhD & Assoc Prof Ondřej Petrák, MD, PhD., 3rd Department of Medicine – Department of Endocrinology and Metabolism, General Faculty Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic.

14. Chapter 13. ACTH dependent Cushing Syndrome. Dr. Stuti Fernandes MD, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health and Science University and VA Hospital; Dr. Elena V Varlamov MD, & Prof Maria Fleseriu MD, FACE, Division of Endocrinology, Diabetes and Clinical Nutrition) and Neurological Surgery, and Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA.

15. Chapter 14. Adrenal Cushing’s syndrome. Assoc Prof Oskar Ragnarsson MD. PhD, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, & Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden.

16. Chapter 15. Hypertension in Growth Hormone Excess (Acromegaly) and Deficiency. Dr. Gabriala Mihai MD, & Prof Márta Korbonits PhD, FRCP, Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

17. Chapter 16. Hypertension in Thyroid disease & hyperparathyroidism. Dr. Naomi Szwarcbard MD, Department of Endocrinology & Diabetes, Alfred Health, Prof Duncan Topliss MD, FRACP, Department of Endocrinology & Diabetes, Alfred Health & Monash University, Melbourne, Australia, Australia.

18. Chapter 17. Obesity, Insulin Resistance, and Obstructive Sleep Apnoea. Dr. Dominic Oduro-Donkor MD, MRCP, & Assoc Prof Thomas M Barber DPhil, FRCP, Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Coventry, UK & Division of Biomedical Sciences, Warwick Medical School, University of Warwick, UK.

19. Chapter 18. Endocrine Hypertension in Children. Dr. Badhma Valaiyapathi MBBS, University of Alabama at Birmingham, USA & Prof Ambika P Ashraf MD, FACE, Division of Pediatric Endocrinology and Diabetes, University of Alabama at Birmingham, USA.

20. Chapter 19. Endocrine Hypertension in Pregnant Woman. Assoc Prof Felix Jebasingh MD, DM, & Prof Nihal Thomas PhD, FRCP, Department of Endocrinology, Christian Medical College Vellore, India.

21. Chapter 20. Imaging for Patients with Endocrine Hypertension. Dr. Katherine Ordidge PhD, FRCR, Department of Imaging, St Bartholomew’s Hospital, Barts Health, London & Prof Anju Sahdev, MRCP, FRCR, Department of Imaging, St Bartholomew’s Hospital, Barts Health and Clinical Professor of Diagnostic Imaging, Barts Cancer Institute, Queen Mary University of London, UK.

22. Chapter 21. Systematic Approach for the Diagnosis and Management of Endocrine Hypertension. Prof Michael Stowasser PhD, FRACP, Endocrine Hypertension Research Centre, University of Queensland, Brisbane, Australia; Dr. Pieter Jansen PhD, FRCAP, Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia & Dr. Martin Wolley PhD, FRACP, Endocrine Hypertension Research Centre, University of Queensland, Australia.