Honoring Our Past
Historic & Seminal Articles
The historical articles in this special collection underscore key advancements in general and internal medicine.

Mayo Clinic Proceedings opens in new tab/window has a legacy of transforming the healthcare landscape through seminal work that has spurred new research, diagnostic approaches, and treatment strategies.
The articles featured in this collection exemplify the foundational contributions that have not only advanced medical knowledge but also continue to influence contemporary practice. By honoring these pivotal studies, we celebrate how their impact resonates in today’s healthcare environment, illustrating the enduring importance of innovation and discovery in shaping our understanding of medicine.