CAS article collection: Chemistry Advancing Health
Highlighting high quality research
Introduction
In the 21st century, with the aim and scope of protecting and improving human health, global scientists including chemists, biologists and physicists are devoted to understanding the basis of diseases, such as malignant tumors, metabolic disorders and Alzheimer’s disease (AD), and to develop novel drugs and diagnostic methods for a better treatment of patients. Chinese Academy of Science (CAS) is one of the leading research institutes in China and scientists from CAS are working at the forefront of chemistry and life science. Here, we would like to present a special article collection highlighting the latest contributions devoted by these scientists from CAS.
With thanks to the Article Selection Editor
Hong Liu is a professor at Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS), and the vice director of State Key Laboratory of Drug Research at SIMM.
Her research efforts are mainly dedicated to researching pharmaceutical chemistry and drug design & discovery. She also focuses on the development of novel organic synthetic methodologies and building focused combinatorial libraries. Dr. Hong Liu has published 310 academic papers in peer-reviewed journals, including Chemical Reviews, Angewandte Chemie International Edition, Journal of Medicinal Chemistry, Chemical Communication, Green Chemistry, Advanced Synthesis & Catalysis, Organic Letters and Journal of Organic Chemistry. Liu has written 12 books as chapter author and applied 56 patents.
She also serves as the associate editor of Bioorganic & Medicinal Chemistry Letters.
Professor Hong Liu
Drug Design and Discovery
Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitorsopens in new tab/window Cui, G., Jin, J., Chen, H., Cao, R., Chen, X., & Xu, B. Bioorganic & Medicinal Chemistry
Design and synthesis of novel C14-urea-tetrandrine derivatives with potent anti-cancer activityopens in new tab/window Lan, J., Huang, L., Lou, H., Chen, C., Liu, T., Hu, S., Yao, Y., Song, J-r., Luo, J., Liu, Y-z.,Xia, B., Xia, L., Zeng, X-y-z., David, Y-B., Pan, W. European Journal of Medicinal Chemistry
Liu, X., Zhang, Y., Huang, W., Tan, W., & Zhang, A. Bioorganic & Medicinal Chemistry
Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitorsopens in new tab/window Wei, M. M., Xia, P., Xing, L., Dai, Y., Huang, R. -M., Geng, M. -Y., Zhang, A., Ai, J., Song, Z. -L. European Journal of Medicinal Chemistry
Discovery, optimization and biological evaluation for novel c-Met kinase inhibitorsopens in new tab/window Yuan, H. -L., Liu, Q. -F., Zhang, L., Hu, S. -H., Chen, T. -T., Li, H. -F., Chen, Y. -D., Xu, Y. C., Lu, T. European Journal of Medicinal Chemistry
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agentsopens in new tab/window Zhou, P., Liang, Y., Zhang, H., Jiang, H., Feng, K., Xu, P., Wang, J., Wang, X., Ding, K., Luo, C., Liu, M., Wang, Y. European Journal of Medicinal Chemistry
Long, L., Luo, Y., Hou, Z. -J., Ma, H. -J., Long, Z. -J., Tu, Z. -C., Huang, L. -J., Liu, Q. -T., Lu, G. European Journal of Medicinal Chemistry
Selective recognition of HIV RNA by dinuclear metallic ligandsopens in new tab/window
Li, X., Chen, B., Lan, L., Wang, R., Luo, D., Liu, L., Cheng, L. Chinese Chemical Letters
Liu, X., Chen, P., Li, X., Ba, M., Jiao, X., Guo, Y., Xie, P. Bioorganic & Medicinal Chemistry
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's diseaseopens in new tab/window Xu, Y.-X., Wang, H., Li, X.-K., Dong, S.-N., Liu, W.-W., Gong, Q., Wang, T.-D., Tang, Y., Zhu, J., Li, J., Zhang, H.-Y., Mao, F. European Journal of Medicinal Chemistry
Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3’,2’:3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2’,3’:4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5’-monophosphateactivated protein kinase (AMPK)opens in new tab/window Gu, Z.-N., Wu, L.-Y., Duan, Y.-N., Wang, J., Zhou, S.-B., Li, J.-Y., Chen, K.-X., Li, J., Liu, H. Bioorganic & Medicinal Chemistry
Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitorsopens in new tab/window Shang, F. -N., Gao, N., Yin, R. -H., Lin L. -S., Xiao, C., Zhou, L. -T., Li, Z., Purcell, S. -W., Wu, M. -Y., Zhao, J. -H. European Journal of Medicinal Chemistry
Bioactive Natural Products
Phytochemical variation among the traditional Chinese medicine Mu Dan Pi from Paeonia suffruticosa (tree peony)opens in new tab/window Li, S.-S., Wu, Q., Yin, D.-D., Feng, C.-Y., Liu, Z.-A., Wang, L.-S. Phytochemistry
Grayanane diterpenoids with diverse bioactivities from the roots of Pieris formosaopens in new tab/window Niu, C.-S., Li, Y., Liu, Y.-B., Ma, S.-G., Liu, F., Cui, L., Yu, H.-B., Wang, X.-J., Qu, J., Yu, S.-S. Tetrahedron
Novel tetrahydrofuran derivatives from Trigonostemon howii with their potential anti-HIV-1 activitiesopens in new tab/window Liu, Y.-P., Zhao, W.-H., Feng, X.-Y., Zhang, Z.-J., Zong, K., Sun, Z.-G., Zheng, Y.-T., Fu, Y.-H. Bioorganic Chemistry
Jatrophane diterpenoids from Euphorbia sororia as potent modulators against P-glycoprotein-based multidrug resistanceopens in new tab/window Hu, R., Gao, J., Rozimamat, R., & Aisa, H. A. European Journal of Medicinal Chemistry
Borrelidins F–I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89opens in new tab/window Sun, J. -B., Shao, J. -L., Sun C. -L., Song, Y. -X., Li, Q. -L., Lu, L. -C., Hu, Y. -F., Gui, C., Zhang, H., Ju, J. -H. Bioorganic & Medicinal Chemistry
Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2opens in new tab/window Weng, Z.-M., Ge, G.-B., Dou, T.-Y., Wang, P., Liu, P.-K., Tian, X.-H., Qiao, N., Yu, Y., Zou, L.-W., Zhou, Q., Zhang, W.-D., Hou, J. Bioorganic Chemistry
Pharmaceutical Metabolism
Yang, S., Liu, H., Huang, X., Zhan, L., Luo, P., Xue, J., Chen, R., Nie, Z. International Journal of Mass Spectrometry
Identification of chemicals and rat metabolites of Biqi capsule by liquid chromatography-tandem mass spectrometry following a network pharmacological analysisopens in new tab/window Zheng, H., Wang, Z., Liu, W., Ren, T., Zhang, J. International Journal of Mass Spectrometry
New Approaches for Disease Diagnosis
Label-free glucose biosensor based on enzymatic graphene oxide-functionalized tilted fiber gratingopens in new tab/window Jiang, B., Zhou, K., Wang, C., Sun, Q., Yin, G., Tai, Z., Wilson, K., Zhao, J., Zhang, L. Sensors and Actuators, B: Chemical
Wang, K., Zhou, W., Lin, Z., Cai, F., Li, F., Wu, J., Meng, L., Niu, L., Zheng, H. Sensors and Actuators, B: Chemical
An electrochemical approach capable of prostate specific antigen assay in human serum based on exonuclease-aided target recycling amplificationopens in new tab/window Miao, P., Jiang, Y., Wang, Y., Yin, J., Tang, Y. Sensors and Actuators, B: Chemical
Sun, X., Li, B., Tian, C., Yu, F., Zhou, N., Zhan, Y., Chen, L. Analytica Chimica Acta
Chemical Probes in Medical Research
Biomarker-targeted fluorescent probes for breast cancer imaging (Review article)opens in new tab/window Yue, D., Wang, M., Deng, F., Yin, W., Zhao, H., Zhao, X., Xu, Z. Chinese Chemical Letters
Xiong, H., Han, J., Wang, J., Lu, W. -C., Wang, C., Chen, Y., Lian, F. -L., Zhang, N. -X., Liu, Y. -C., Zhang, C. -H., Ding, H., Jiang, H. -L., Lu, W. -C., Luo, C., Zhou, B. European Journal of Medicinal Chemistry
New Analytical Techniques for Food Safety
Utilization of a lateral flow colloidal gold immunoassay strip based on surface-enhanced Raman spectroscopy for ultrasensitive detection of antibiotics in milkopens in new tab/window Shi, Q., Huang, J., Sun, Y., Yin, M., Hu, M., Hu, X., Zhang, Z., Zhang, G. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Quantitative structure-retention relationships model for retention time prediction of veterinary drugs in food matrixesopens in new tab/window Noreldeen, H.A.A., Liu, X., Wang, X., Fu, Y., Li, Z., Lu, X., Zhao, C., Xu, G. International Journal of Mass Spectrometry
New Analytical Techniques for Biomedical Research
Qu, F., Chen, Z., You, J., Song, C. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TOopens in new tab/window
Gu, Y., Lin, D., Tang, Y., Fei, X., Wang, C., Zhang, B., Zhou, J. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Coumarin/fluorescein-fused fluorescent dyes for rapidly monitoring mitochondrial pH changes in living cellsopens in new tab/window Qi, S., Li, Q., Liu, W., Ren, H., Zhang, H., Wu, J., Ge, J., Wang, P. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Mass spectrometry imaging of intact cholesterol in a mouse esophagus tissue section and mouse zygotes using VUV laser desorption/ionization methodopens in new tab/window Wang, J., Wang, Z., Liu, F., Mo, Y., Cai, L., Sun, C., Zhang, S., Zhang, R., Abliz, Z., Zhang, X. International Journal of Mass Spectrometry
Zhao, N.-N., Sun, Y.-F., Zong, L., Liu, S., Song, F.-R., Liu, Z.-Q., Liu, S.-Y. International Journal of Mass Spectrometry
Association of alteration of nucleosides and nucleotides with gastric cancer microenvironmentopens in new tab/window Guo, S., Wang, Y., Zhou, D., Xu, Y., Chen, T., Li, Z. International Journal of Mass Spectrometry
Biosensors and Bioelectronics
Carbon dots based photoelectrochemical sensors for ultrasensitive detection of glutathione and its applications in probing of myocardial infarctionopens in new tab/window Li, Z., Zhang, J., Li, Y., Zhao, S., Zhang, P., Zhang, Y., Bi, J., Liu, G., Yue, Z. Biosensors and Bioelectronics
Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensoropens in new tab/window Zhang, J., Khan, I., Zhang, Q., Liu, X., Dostalek, J., Liedberg, B., Wang, Y. Biosensors and Bioelectronics
Electrochemical integrated paper-based immunosensor modified with multi-walled carbon nanotubes nanocomposites for point-of-care testing of 17β-estradiolopens in new tab/window Wang, Y., Luo, J., Liu, J., Li, X., Kong, Z., Jin, H., Cai, X. Biosensors and Bioelectronics
Lin, S., Feng, W., Miao, X., Zhang, X., Chen, S., Chen, Y., Wang, W., Zhang, Y. Biosensors and Bioelectronics
Robust hybrid enzyme nanoreactor mediated plasmonic sensing strategy for ultrasensitive screening of anti-diabetic drugopens in new tab/window Kong, W., Wu, D., Hu, N., Li, N., Dai, C., Chen, X., Suo, Y., Li, G., Wu, Y. Biosensors and Bioelectronics
Metabolomics Data Analysis
Comprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selectionopens in new tab/window Li, Z., Lu, Y., Guo, Y., Cao, H., Wang, Q., Shui, W. Analytica Chimica Acta