Otto Warburg Medal Award

2024 Otto Warburg Medal Award

We are delighted to announce that the 2024 Otto Warburg Medal Award has been presented to Professor Dr. Johannes Buchner in recognition of his fundamental contributions to protein structure formation and the role of chaperones.

BBA Collection Otto Warburg 2024: Protein structure formation and the role of chaperones

This curated compilation, sourced from the family of ten BBA Journals over the period 2018-2024, serves as a tribute to Professor Dr. Johannes Buchner. Dr. Buchner is the 2024 recipient of the Otto Warburg Medal Award, an award which BBA is honoured to sponsor. Professor Buchner has made pioneering contributions to many different aspects of protein science, in particular to the role of chaperones in safeguarding protein folding and antibody stability. These proteins are “protectors”, either of the organism itself or of the many different proteins whose correct folding is a prerequisite for their function. The articles compiled are original research and reviews published across the BBA journals that illustrate the breadth and complexity of these proteins.

Structural studies of the Hsp70/Hsp90 organizing protein of Plasmodium falciparum and its modulation of Hsp70 and Hsp90 ATPase activitiesopens in new tab/window Noeli S.M. Silva, Dayane E. Bertolino-Reis, Paulo R. Dores-Silva, Fátima B. Anneta, Thiago V. Seraphim, Leandro R.S. Barbosa, Júlio C. Borges, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020

Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopyopens in new tab/window Futoshi Ihama, Mami Yamamoto, Chojiro Kojima, Toshimichi Fujiwara, Katsumi Matsuzaki, Yoshihiko Miyata, Masaru Hoshino, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2019

Detection of key sites of dimer dissociation and unfolding initiation during activation of acid-stress chaperone HdeA at low pHopens in new tab/window Marlyn A. Widjaja, Jafaeth S. Gomez, Jonathon M. Benson, Karin A. Crowhurst, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020

Biophysical characterization of human-cell-expressed, full-length κI O18/O8, AL-09, λ6a, and Wil immunoglobulin light chainsopens in new tab/window Pinaki Misra, Alexander Tischer, Lindsey Lampe, Valeria Pierluissi-Ruiz, Christopher J. Dick, Benoit Bragantini, Nikita Kormshchikov, Matthew Auton, Marina Ramirez-Alvarado, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2024

Amyloid fibril formation by αS1- and β-casein implies that fibril formation is a general property of casein proteinsopens in new tab/window Elmira Bahraminejad, Devashi Paliwal, Margaret Sunde, Carl Holt, John A. Carver, David C. Thorn, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2022

Engineering of conserved residues near antibody heavy chain complementary determining region 3 (HCDR3) improves both affinity and stabilityopens in new tab/window Merve Arslan, Tuğçe Uluçay, Seyit Kale, Sibel Kalyoncu, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2023

Structure and energetic basis of overrepresented λ light chain in systemic light chain amyloidosis patientsopens in new tab/window Jun Zhao, Baohong Zhang, Jianwei Zhu, Ruth Nussinov, Buyong Ma, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018

Inhibition of amyloid fibril formation in the variable domain of λ6 light chain mutant Wil caused by the interaction between its unfolded state and epigallocatechin-3-O-gallateopens in new tab/window Yoshito Abe, Naoki Odawara, Nantanat Aeimhirunkailas, Hinako Shibata, Naoki Fujisaki, Hirofumi Tachibana, Tadashi Ueda, Biochimica et Biophysica Acta (BBA) - General Subjects, 2018

Localized conformational changes trigger the pH-induced fibrillogenesis of an amyloidogenic λ light chain proteinopens in new tab/window Isabel Velázquez-López, Gilberto Valdés-García, Sergio Romero Romero, Roberto Maya Martínez, Ana I. Leal-Cervantes, Miguel Costas, Rosana Sánchez-López, Carlos Amero, Nina Pastor, D. Alejandro Fernández Velasco, Biochimica et Biophysica Acta (BBA) - General Subjects, 2018

Chemical chaperone 4-phenylbutyric acid alleviates the aggregation of human familial pulmonary fibrosis-related mutant SP-A2 protein in part through effects on GRP78opens in new tab/window Xu Jiang, Guodong Fang, Li Dong, Peifeng Jin, Lu Ding, Haizeng Zhang, Junming Fan, Sunzhong Mao, Xiaofang Fan, Yongsheng Gong, Yongyu Wang, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018

Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperoneopens in new tab/window Yoshihiko Miyata, Eisuke Nishida, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2021

Molecular chaperone function of stress inducible Hsp70 is critical for intracellular multiplication of Toxoplasma gondiiopens in new tab/window Pallabi Mitra, Abhijit S. Deshmukh, Chinmayee Choudhury, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020

Amino acid transporter SLC6A14 depends on heat shock protein HSP90 in trafficking to the cell surfaceopens in new tab/window Karolina Rogala-Koziarska, Łukasz Samluk, Katarzyna A. Nałęcz, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2019

HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competitionopens in new tab/window Sikai Wang, Hongxia Cheng, Yilan Huang, Miaomiao Li, Dongmei Gao, Huaping Chen, Ruxiong Su, Kun Guo, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2024

A novel role of HSP90 in regulating osteoclastogenesis by abrogating Rab11b-driven transportopens in new tab/window Manh Tien Tran, Yuka Okusha, Yunxia Feng, Chiharu Sogawa, Takanori Eguchi, Tomoko Kadowaki, Eiko Sakai, Takayuki Tsukuba, Kuniaki Okamoto, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2021

Prospects and challenges of noncoding-RNA-mediated inhibition of heat shock protein 90 for cancer therapyopens in new tab/window Shria Mattoo, Abha Gupta, Manvee Chauhan, Akshi Agrawal, Subrata Kumar Pore, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2024

DNAJB12 and DNJB14 are non-redundant Hsp40 redox chaperones involved in endoplasmic reticulum protein refluxopens in new tab/window Aline Dias da Purificação, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Verônica de Mello Gabriel, João Wosniak Júnior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira, Biochimica et Biophysica Acta (BBA) - General Subjects, 2023

Distinct dynamical features of plasmodial and human HSP70-HSP110 highlight the divergence in their chaperone-assisted protein foldingopens in new tab/window Aradhya Tripathi, Sara Del Galdo, Balasubramanian Chandramouli, Niti Kumar, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2023

HSPA1A conformational mutants reveal a conserved structural unit in Hsp70 proteinsopens in new tab/window Veronika Vandova, Pavla Vankova, Michal Durech, Josef Houser, Daniel Kavan, Petr Man, Petr Muller, Filip Trcka, Biochimica et Biophysica Acta (BBA) - General Subjects, 2020

Association of Hsp90 with p53 and Fizzy related homolog (Fzr) synchronizing Anaphase Promoting Complex (APC/C): An unexplored ally towards oncogenic pathwayopens in new tab/window Sanghati Roy Chowdhury, Tirthankar Koley, Mandeep Singh, Abdul Samath Ethayathulla, Punit Kaur, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2023

Human HSPA9 (mtHsp70, mortalin) interacts with lipid bilayers containing cardiolipin, a major component of the inner mitochondrial membraneopens in new tab/window Paulo Roberto Dores-Silva, David M. Cauvi, Vanessa T.R. Kiraly, Júlio C. Borges, Antonio De Maio, Biochimica et Biophysica Acta (BBA) – Biomembranes, 2020

Advances in chaperone-assisted RNA crystallography using synthetic antibodiesopens in new tab/window Hasan Al Banna, Naba Krishna Das, Manju Ojha, Deepak Koirala, BBA Advances, 2023

The roles of the chaperone-like protein CpeZ and the phycoerythrobilin lyase CpeY in phycoerythrin biogenesisopens in new tab/window Christina M. Kronfel, Avijit Biswas, Jacob P. Frick, Andrian Gutu, Tyler Blensdorf, Jonathan A. Karty, David M. Kehoe, Wendy M. Schluchter, Biochimica et Biophysica Acta (BBA) – Bioenergetics, 2019