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Clinicalkey AI in action: What are indications for plasma exchange in severe babesiosis

| Lecture de 2 min

ClinicalKey AI combines trusted, evidence-based clinical content with conversational search powered by generative AI to support clinicians in delivering high-quality patient care.  Clinicians gain a powerful ally with ClinicalKey AI by providing quick access to trusted clinical knowledge and allowing them to focus on what truly matters, quality patient care. Interested healthcare organizations can contact us today to learn more.  

ClinicalKey AI Query: What are indications for plasma exchange in severe babesiosis

Plasma exchange, also known as exchange blood transfusion, is indicated in severe babesiosis in cases of high-grade parasitemia (10% or more of erythrocytes), severe hemolytic anemia (less than 10 g/dL), pulmonary, renal, or hepatic impairment, and Babesia divergens infection.[1-2]

  • Exchange blood transfusion is used to rapidly decrease parasite burden and clear toxic byproducts from circulation.[1]

  • The procedure can be either partial or complete, depending on the severity of the disease.[1]

  • It is capable of reducing parasitemia by 90%, and limited data suggest early use (within approximately 1.5 days after presentation) of exchange transfusion may prevent organ dysfunction.[1]

  • In addition to antibiotic treatment, partial or complete red cell exchange transfusion should be considered in severely ill patients with parasitemias in excess of 10%, evidence of severe hemolysis, or organ compromise.[3]

  • A systematic review suggests that apheresis may be a useful adjunct in the treatment of patients hospitalized for babesiosis.[4]

  1. Babesiosis.S’ouvre dans une nouvelle fenêtre  Elsevier ClinicalKey  Clinical Overview 

  2. Babesiosis (Babesia).S’ouvre dans une nouvelle fenêtre  Krause, Peter J.  Book Chapter 

  3. Babesiosis and Other Protozoan Diseases.S’ouvre dans une nouvelle fenêtre  Telford, Sam R., Krause, Peter J. In Goldman-Cecil Medicine (pp. 2151). 

  4. Safety and Effectiveness of Apheresis in the Treatment of Infectious Diseases: A Systematic Review.S’ouvre dans une nouvelle fenêtre  Odedra A, Lalloo DG, Kennedy G, Llewellyn S, McCarthy JS.  The Journal of Infection. 2019;79(6):513-520. doi:10.1016/j.jinf.2019.09.014. 

Answer generated on April 2, 2024 

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