メインのコンテンツにスキップする

申し訳ございませんが、お客様のブラウザには完全に対応しておりませんオプションがありましたら、新しいバージョンにアップグレードするか、 Mozilla Firefox、 Microsoft Edge、Google Chrome、またはSafari 14以降をお使いください。これらが利用できない場合、またサポートが必要な場合は、フィードバックをお送りください。

この新ホームページへのフィードバックを歓迎します。ご意見をお寄せください新しいタブ／ウィンドウで開く

Elsevier
論文を投稿する
Video

ClinicalKey AI in action: Can I use an SGLT2 agent for management of HFpEF in a non-diabetic patient

| 2 分経過

ClinicalKey AI combines trusted, evidence-based clinical content with conversational search powered by generative AI to support clinicians in delivering high-quality patient care.  Clinicians gain a powerful ally with ClinicalKey AI by providing quick access to trusted clinical knowledge and allowing them to focus on what truly matters, quality patient care. Interested healthcare organizations can contact us today to learn more.  

SGLT

Yes, you can use a sodium-glucose co-transporter-2 (SGLT2) inhibitor such as empagliflozin or dapagliflozin for the management of heart failure with preserved ejection fraction (HFpEF) in a non-diabetic patient. SGLT2 inhibitors like empagliflozin and dapagliflozin have been shown to reduce the risk of hospitalization for heart failure and improve symptoms and health-related quality of life in patients with HFpEF, regardless of their diabetes status.[1-3] The EMPEROR-Preserved trial demonstrated improved outcomes (21% reduction in cardiovascular death or HF hospitalization) in patients with HFpEF treated with empagliflozin, with benefits established in both diabetic and non-diabetic patients.[2][4] The DELIVER trial, which tested dapagliflozin, is expected to report its results soon, and it is anticipated that it may provide further evidence supporting the use of SGLT2 inhibitors in HFpEF.[3] The FDA has approved the use of empagliflozin for reducing the risk of cardiovascular death and HF hospitalization in patients with HFpEF.[2][5] Sotagliflozin, an SGLT1/2 inhibitor, has also been shown to reduce heart failure hospitalization in patients with HFpEF.[3][6]

  1. Heart Failure新しいタブ／ウィンドウで開く. McMurray, John J.V., Pfeffer, Marc A. In Goldman-Cecil Medicine (pp. 262).

  2. Chronic Heart Failure With Preserved Ejection Fraction, Management. 新しいタブ／ウィンドウで開く Elsevier ClinicalKey Clinical Overview

  3. Heart Failure with Preserved and Mildly Reduced Ejection Fraction. 新しいタブ／ウィンドウで開く Lam,, Carolyn S.P., Shah,, Sanjiv J., Solomon, Scott D. In Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine (pp. 1007).

  4. Empagliflozin in Heart Failure With a Preserved Ejection Fraction.新しいタブ／ウィンドウで開く Anker SD, Butler J, Filippatos G, et al. The New England Journal of Medicine. 2021;385(16):1451-1461. doi:10.1056/NEJMoa2107038.

  5. JARDIANCE. Label via DailyMed新しいタブ／ウィンドウで開く. Food and Drug Administration (DailyMed) FDA

  6. INPEFA. Label via DailyMed新しいタブ／ウィンドウで開く. Food and Drug Administration (DailyMed) FDA Answer generated on March 31, 2024 Note: User acknowledges that these materials are provided for use at no charge as part of Elsevier’s efforts to support healthcare providers and patients. The information contained within the website is intended as a supplement to, and not a substitute for, the knowledge, expertise, skill and judgment of healthcare professionals involved in patient care. The content within this page may not be re-used, modified or re-distributed without prior written permission.