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AI-Generated response:

Are allergic reactions common to albumin infusions?

Answer generated on June 4, 2024

The AI-generated responses are for illustration purposes only and should not be used for medical purposes.

Yes, allergic reactions are common to albumin infusions.

  • Anaphylactoid reactions are the most common adverse events seen with albumin infusions, including symptoms such as anaphylactic shock, angioedema, urticaria, rash, erythematous rash, and pruritus.[1]

  • Other allergic manifestations may include changes in respiration, pulse, and blood pressure, which are significant indicators of a hypersensitivity reaction.[1]

  • Symptoms like fever, chills, hyperhidrosis, and edema may also be components of an allergic reaction to albumin.[1]

  • Respiratory changes such as pulmonary edema, dyspnea, and bronchospasm have been reported and may be indicative of an allergic reaction or hypervolemia.[1]

  • Albumin use is contraindicated in patients with a known hypersensitivity to albumin or any of its excipients, and administration should be discontinued immediately if hypersensitivity is suspected.[1]

Additional info

It is crucial for clinicians to be aware of the potential for allergic reactions when administering albumin and to monitor patients closely for any signs of hypersensitivity. Immediate discontinuation of the infusion and appropriate medical intervention are necessary at the first signs of an allergic reaction. This includes monitoring for less obvious signs of allergic reactions such as changes in blood pressure or respiratory distress, which might not be immediately recognized as related to an allergic response. The presence of excipients in the albumin solution can also contribute to hypersensitivity reactions, and thus, awareness of the specific formulation used is important.

References

Reference 1

1.

Elsevier ClinicalKey Drug Monograph

Content last updated: September 5, 2023.

Adverse Reactions Anaphylactoid reactions are the most common adverse events seen with albumin. Hypersensitivity/allergic reactions including anaphylactic shock, angioedema, urticaria, rash, erythematous rash, and pruritus have been reported with albumin use. Allergic manifestations may also include changes in respiration, pulse, and blood pressure.

Adverse Reactions Fever, chills, hyperhidrosis, and edema have been reported with albumin use. These symptoms may be a component of an allergic reaction.

Adverse Reactions Pulmonary edema, dyspnea, and bronchospasm have been reported with albumarc use. Changes in respiration may be a result of an allergic reaction or hypervolemia. If hypervolemia is suspected, adjust dose and rate of infusion to the patient's volume status. Discontinue albumarc administration at the first sign of cardiovascular overload or if hypersensitivity is suspected.

Contraindications And Precautions Use of albumarc is contraindicated in patients with a history of albumarc hypersensitivity or hypersensitivity to any of the excipients. Discontinue administration immediately and institute appropriate medical treatment if a hypersensitivity reaction is suspected.

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