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AI-Generated response:

Is dihidroberberine good for blood glucose control?

Answer generated on June 4, 2024

The AI-generated responses are for illustration purposes only and should not be used for medical purposes.

Dihydroberberine has not shown significant effects on blood glucose control in the context of the study referenced.[1]

  • The study was a randomized, controlled, crossover pilot trial that compared the effects of dihydroberberine and berberine on blood glucose and insulin levels.[1]

  • Participants received either 100 mg or 200 mg doses of dihydroberberine, or a 500 mg dose of berberine, or a placebo.[1]

  • No significant differences in glucose (p = 0.97) and insulin levels (p = 0.24) were observed across the different interventions in the study.[1]

  • The lack of observed changes in glucose and insulin levels was attributed to the short duration of supplementation and the insulin-responsive nature of the study participants.[1]

  • The study suggests that further research is needed, particularly in populations that are overweight and glucose intolerant, to fully assess the impact of dihydroberberine on glucose and insulin levels.[1]

Additional info

The study referenced provides preliminary evidence regarding the absorption kinetics of dihydroberberine compared to berberine, indicating that dihydroberberine achieves higher plasma concentrations. However, these increased concentrations did not translate into significant changes in glucose or insulin levels during the short duration of the trial. This suggests that while dihydroberberine may be better absorbed, its effectiveness in controlling blood glucose under the conditions of this study was not demonstrated. Further long-term studies in appropriate populations are necessary to determine if dihydroberine can be beneficial for blood glucose control in clinical practice.

References

Reference 1

1.

Moon JM, Ratliff KM, Hagele AM, et al. Nutrients. 2021;14(1):124. doi:10.3390/nu14010124. Copyright License: CC BY

Publish date: December 2, 2021.

No significant differences in the levels of glucose ( = 0.97) and insulin ( = 0.24) were observed across the study protocol. These results provide preliminary evidence that four doses of a 100 mg dose of dihydroberberine and 200 mg dose of dihydroberberine produce significantly greater concentrations of plasma berberine across of two-hour measurement window when compared to a 500 mg dose of berberine or a placebo. The lack of observed changes in glucose and insulin were likely due to the short duration of supplementation and insulin responsive nature of study participants. Follow-up efficacy studies on glucose and insulin changes should be completed to assess the impact of berberine and dihydroberberine supplementation in overweight, glucose intolerant populations.

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