Skip to main content

Unfortunately we don't fully support your browser. If you have the option to, please upgrade to a newer version or use Mozilla Firefox, Microsoft Edge, Google Chrome, or Safari 14 or newer. If you are unable to, and need support, please send us your feedback.

We'd appreciate your feedback.Tell us what you think! opens in new tab/window

Elsevier
Publish with us
AI-Generated response:

What are contraindications of using propofol?

Answer generated on June 4, 2024

The AI-generated responses are for illustration purposes only and should not be used for medical purposes.

Propofol is contraindicated in patients with known hypersensitivity to propofol or any of its components, including egg, soy, or peanut products, and in those with sulfite hypersensitivity.[1-3]

  • Propofol should not be used in patients allergic to eggs, egg products, soybeans, or soy products due to the risk of severe allergic reactions.

  • It is also contraindicated in patients with a history of peanut hypersensitivity when using specific formulations like Fresenius Propoven.

  • Some formulations of propofol contain sodium metabisulfite, which can cause allergic-type reactions, including anaphylactic symptoms, particularly in susceptible individuals such as those with asthma.

  • Propofol requires administration by experienced clinicians in specialized care settings due to the potential for severe side effects like hypotension, apnea, and oxygen desaturation.

  • It is also contraindicated in settings where there is a risk of propofol infusion syndrome, particularly in pediatric intensive care units or when used at high doses for prolonged periods.

Additional info

Propofol administration demands careful monitoring and specific clinical expertise due to its complex safety profile. Facilities must be equipped for immediate intervention in cases of cardiorespiratory compromise. The drug's use in certain patient populations, such as those with severe cardiac disease or unstable hemodynamics, requires cautious management and often precludes its use due to the risk of exacerbated hypotension or cardiac complications. Additionally, the risk of propofol-related infusion syndrome, particularly in pediatric patients or those receiving high doses, necessitates alternative sedation strategies and close monitoring of metabolic parameters. These considerations underscore the importance of adhering strictly to contraindications and precautions to mitigate risks associated with propofol use.

References

Reference 1

1.

Elsevier ClinicalKey Drug Monograph

Content last updated: April 5, 2024.

Contraindications And Precautions Propofol is contraindicated in patients with a known hypersensitivity to propofol or to any of the components , which include soybean oil and egg phospholipid; therefore, propofol is also contraindicated in patients with egg hypersensitivity or soya lecithin hypersensitivity. Fresenius Propoven is also contraindicated in patients with peanut hypersensitivity. Certain formulations of propofol contain sodium metabisulfite. Sodium metabisulfite is a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe episodes in certain susceptible people, such as patients with sulfite hypersensitivity or asthma.

Contraindications 4 CONTRAINDICATIONS Propofol injectable emulsion is contraindicated in patients with a known hypersensitivity to propofol or any of propofol injectable emulsion components. Propofol injectable emulsion is contraindicated in patients with a history of anaphylaxis to eggs, egg products, soybeans or soy products. Known hypersensitivity to propofol, egg or soybean ( 4 )

Reference 2

2.

Food and Drug Administration (DailyMed).

Publish date: November 1, 2023.

Contraindications CONTRAINDICATIONS: Diprivan (propofol) is contraindicated in patients with a known hypersensitivity to Diprivan (propofol) or any of Diprivan (propofol) components. Diprivan (propofol) is contraindicated in patients with allergies to eggs, egg products, soybeans or soy products.

Reference 3

3.

Food and Drug Administration (DailyMed).

Publish date: September 5, 2022.

Contraindications 4 CONTRAINDICATIONS Propofol injectable emulsion is contraindicated in patients with a known hypersensitivity to propofol or any of propofol injectable emulsion components. Propofol injectable emulsion is contraindicated in patients with a history of anaphylaxis to eggs, egg products, soybeans or soy products. Known hypersensitivity to propofol, egg or soybean ( 4 )

Follow up questions