World Cancer Day, 4 February 2025

Join us in commemorating World Cancer Day on 4th February by exploring our specially curated collection of articles that delve into the multi-faceted aspects of this pervasive disease. This collection will provide you with a comprehensive overview of the latest advancements in cancer research and treatment.

Annals of Oncology

• Acquired gene alterations in patients treated with ribociclib plus endocrine therapy or endocrine therapy alone using baseline and end-of-treatment circulating tumor DNA samples in the MONALEESA-2, -3, and -7 trials opens in new tab/window

• Tocilizumab provides dual benefits in treating immune checkpoint inhibitor-associated arthritis and preventing relapse during ICI rechallenge: the TAPIR study opens in new tab/window

Blood Neoplasia

• Real-world comparison of daratumumab-based regimens in relapsed/refractory multiple myeloma using health record data opens in new tab/window

• Venetoclax and hypomethylating agents in octogenarians and nonagenarians with acute myeloid leukemia opens in new tab/window

Cancer Epidemiology

• Ovarian cancer survival by stage, histotype, and pre-diagnostic lifestyle factors, in the prospective UK Million Women Study opens in new tab/window

• Global burden of ototoxic hearing loss associated with platinum-based cancer treatment: A systematic review and meta-analysis opens in new tab/window

• ​Effect of post-diagnosis exercise on depression symptoms, physical functioning and mortality in breast cancer survivors: A systematic review and meta-analysis of randomized control trials opens in new tab/window

• Demographic and socioeconomic disparities in pediatric cancer in the United States: Current knowledge, deepening understanding, and expanding intervention opens in new tab/window

Clinical Breast Cancer

• Risk of Recurrence in Patients with HER2+ Early-Stage Breast Cancer: Literature Analysis of Patient and Disease Characteristics opens in new tab/window

• A phase II single-arm study of palbociclib in patients with HER2-positive breast cancer with brain metastases and analysis of ctDNA in patients with active brain metastases opens in new tab/window

• Robotics in Screening, Diagnosis and Treatment of Breast Cancer: A Perspective View opens in new tab/window

Clinical Colorectal Cancer

• ROCKET: Phase II Randomized, Active-controlled, Multicenter Trial to Assess the Safety and Efficacy of RRx-001 + Irinotecan vs. Single-agent Regorafenib in Third/Fourth Line Colorectal Cancer opens in new tab/window

• Colorectal Cancer Screening Disparities Among Race: A Zip Code Level Analysis opens in new tab/window

• Napabucasin Plus FOLFIRI in Patients With Previously Treated Metastatic Colorectal Cancer: Results From the Open-Label, Randomized Phase III CanStem303C Study opens in new tab/window

Clinical Genitourinary Cancer

• Treatment Rechallenge With Immune Checkpoint Inhibitors in Advanced Urothelial Carcinoma opens in new tab/window

• Antibody-Drug Conjugates in Prostate Cancer: Where Are We? opens in new tab/window

Clinical Lung Cancer

• Liquid Biopsy Versus Tissue Biopsy to Determine Front Line Therapy in Metastatic Non-Small Cell Lung Cancer (NSCLC) opens in new tab/window

• 5-Year Real-World Outcomes With Frontline Pembrolizumab Monotherapy in PD-L1 Expression ≥ 50% Advanced NSCLC opens in new tab/window

• Trends in Stage I Lung Cancer opens in new tab/window

Clinical Lymphoma, Myeloma and Leukemia

• Real-World Use of Fedratinib for Myelofibrosis Following Prior Ruxolitinib Failure: Patient Characteristics, Treatment Patterns, and Clinical Outcomes opens in new tab/window

• The Dynamics of Financial Toxicity in Multiple Myeloma opens in new tab/window

Clinical Oncology

• DNA Repair Genetics and the Risk of Radiation Pneumonitis in Patients with Lung Cancer: A Systematic Review and Meta-analysis opens in new tab/window

• OSAIRIS: Lessons Learned From the Hospital-Based Implementation and Evaluation of an Open-Source Deep-Learning Model for Radiotherapy Image Segmentation opens in new tab/window

• Patient Experiences of Using Wearable Health Monitors During Cancer Treatment: A Qualitative Study opens in new tab/window

• Socioeconomic Deprivation Correlates With Incomplete Radiotherapy Treatment in Head and Neck Cancer opens in new tab/window

• Tumor Infiltrating Lymphocytes and Radiation Therapy in Rectal Cancer: Systematic Review and Meta-analysis opens in new tab/window

Critical Reviews in Oncology/Hematology

• Detecting BRAF mutations in colorectal cancer in clinical practice: An Italian experts' position paper opens in new tab/window

• Grading the evidence for physical activity and any outcome in cancer survivors: An Umbrella review of 740 meta-analytic associations opens in new tab/window

ESMO Gastrointestinal Oncology

• Concomitant proton pump inhibitors and capecitabine-based chemoradiotherapy in rectal cancer: an ancillary study from the PRODIGE 23 trial opens in new tab/window

• Managing zolbetuximab-induced nausea and vomiting: a proposal for a pragmatic approach in clinical practice opens in new tab/window

ESMO Open

• Progressive natural killer cell dysfunction in advanced-stage clear-cell renal cell carcinoma and association with clinical outcomes opens in new tab/window

• Results of a patient-level pooled analysis of three studies of trastuzumab deruxtecan in HER2-positive breast cancer with active brain metastasis opens in new tab/window

ESMO Real World Data and Digital Oncology

• Human epidermal growth factor receptor 2 (HER2) expression dynamics between diagnosis and recurrence in patients with breast cancer using artificial intelligence and electronic health records: the RosHER study opens in new tab/window

• Off-label drug use in oncology: integrating molecular and genetic analysis in an academic center’s real-world approach opens in new tab/window

European Journal of Surgical Oncology

• Lymph Node Metastasis Prediction Model for Each Lymph Node Station in Gastric Cancer Patients opens in new tab/window

• Multimodal prehabilitation in elective oncological colorectal surgery enhances postoperative functional recovery: a secondary analysis of the PREHAB randomized clinical trial opens in new tab/window

• Prediction and validation of pathologic complete response for locally advanced rectal cancer under neoadjuvant chemoradiotherapy based on a novel predictor using interpretable machine learning opens in new tab/window

• Robotic beyond total mesorectal excision for locally advanced rectal cancers: Perioperative and oncological outcomes from a multicentre case series opens in new tab/window

Gynecological Oncology Reports

• Cervical cancer management in a low resource setting: A 10-year review in a tertiary care hospital in Kenya opens in new tab/window

• Information needs during cancer care: Qualitative research with locally advanced cervical cancer patients in Brazil, China, Germany, & the US opens in new tab/window

• Public health concern-driven insights and response of low- and middle-income nations to the World Health Organization call for cervical cancer risk eradication opens in new tab/window

International Journal of Gynecological Cancer

• Minimally invasive compared to open surgery in patients with low-risk cervical cancer following simple hysterectomy: An exploratory analysis from the Gynecologic Cancer Intergroup/Canadian Cancer Trials Group CX.5/SHAPE trial opens in new tab/window

• The prognostic impact of molecular classification in endometrial cancer that undergoes fertility-sparing treatment opens in new tab/window

JACC: CardioOncology

• Modifiable Cardiometabolic Risk Factors in Survivors of Childhood Cancer: JACC: CardioOncology State-of-the-Art Review  opens in new tab/window

• Cardiovascular Concerns, Cancer Treatment and Biological and Chronological Aging in Cancer: JACC Family Series opens in new tab/window

• Social Determinants of Health in Cardio-Oncology: Multi-level strategies to Overcome Disparities in Care: JACC: CardioOncology State-of-the-Art Review opens in new tab/window

• Air Pollution in Cardio-oncology and Unraveling the Environmental Nexus: JACC: CardioOncology State-of-the-Art Review opens in new tab/window

Journal of Bone Oncology

• Immune checkpoint inhibitors in bone metastasis: Clinical challenges, toxicities, and mechanisms opens in new tab/window

• Reprogramming of glucose metabolism: Metabolic alterations in the progression of osteosarcoma opens in new tab/window

• Targeting transforming growth factor beta signaling in metastatic osteosarcoma opens in new tab/window

Journal of Cancer Policy

• Cancer literacy – Informing patients and implementing shared decision making opens in new tab/window

• Current perspectives for external control arms in oncology clinical trials: Analysis of EMA approvals 2016–2021 opens in new tab/window

• FDA validation of surrogate endpoints in oncology: 2005–2022 opens in new tab/window

• Lost productivity due to head and neck cancer mortality in Hungary, Poland, and Romania opens in new tab/window

• Understanding the challenges of delivering radiotherapy in low- and middle-income countries in Africa opens in new tab/window

Journal of Liquid Biopsy

• Circulating tumor DNA kinetics: A future tool for radiation therapy personalization in lung cancer? opens in new tab/window

• Expanding the clinical utility of liquid biopsy by using liquid transcriptome and artificial intelligence opens in new tab/window

Journal of Thoracic Oncology

See the World Cancer Day 2025 Article Collection from Journal of Thoracic Oncology here. opens in new tab/window

Leukemia Research

• Real-world impact of luspatercept on red blood cell transfusions among patients with myelodysplastic syndromes: A United States healthcare claims database study opens in new tab/window

• Recent progress in pathological understanding of adult T-cell leukemia/lymphoma in the new classification era opens in new tab/window

• Treatment of Vietnamese patients diagnosed with myelodysplastic neoplasms: Practical experience in a developing country opens in new tab/window

• When the mask slips: A peripheral T-cell lymphoma disguised as lupus with myelofibrosis in a patient with May-Hegglin syndrome opens in new tab/window

Leukemia Research Reports

• Treatment of Vietnamese patients diagnosed with myelodysplastic neoplasms: Practical experience in a developing country opens in new tab/window

• When the mask slips: A peripheral T-cell lymphoma disguised as lupus with myelofibrosis in a patient with May-Hegglin syndrome opens in new tab/window

Oral Oncology

• HER2-targeted therapies for salivary gland cancers opens in new tab/window

• PRT543, a protein arginine methyltransferase 5 inhibitor, in patients with advanced adenoid cystic carcinoma: An open-label, phase I dose-expansion study opens in new tab/window

Oral Oncology Reports

• Epidemiology and survival analysis of head and neck cancer: Results from comprehensive care center in North India opens in new tab/window

• Trends in the applications of terahertz radiation in oral oncology treatments opens in new tab/window

International Journal of Radiation Oncology, Biology, Physics

• The Lancet Oncology Commission: Radiotherapy & Theranostic Services in LMICs: Minding & Mending the Gaps opens in new tab/window

Seminars in Oncology

• Outcomes with panobinostat in heavily pretreated multiple myeloma patients opens in new tab/window

• PARP inhibitors: A review of the pharmacology, pharmacokinetics, and pharmacogenetics opens in new tab/window

Seminars in Ultrasound, CT and MRI

• Imaging Prognostic Biomarkers in Hepatocellular Carcinoma: A Comprehensive Review opens in new tab/window

• The Ninth Edition TNM Staging Classification for Thymic Epithelial Tumors opens in new tab/window

• Ultrasound of Skin Cancer: What We Need to Know opens in new tab/window

Surgical Oncology

• Machine learning for predicting colon cancer recurrence opens in new tab/window

• Melanoma sentinel lymph node biopsy in the modern era opens in new tab/window

• Robotic distal pancreatectomy using a docking-free system (the hinotori™ Surgical Robot System) opens in new tab/window

Surgical Oncology Insight

• Assessing the OPRA trial for surgical oncologists: Safety and feasibility of a total neoadjuvant therapy approach in patients with rectal cancer opens in new tab/window

• Multidisciplinary management of pleomorphic dermal sarcoma of the scalp: A single institution study opens in new tab/window

• A practical approach for drain fluid analysis following genitourinary surgery opens in new tab/window

• Evolving patterns of metastatic spread, treatment, and outcome for patients with oligometastatic colorectal cancer opens in new tab/window

• Intra-pleural and intra-peritoneal tocilizumab therapy for managing malignant pleural effusions and ascites: The Regional Immuno-Oncology Trial (RIOT)-2 study protocol opens in new tab/window

• Miscategorized lymph nodes in colorectal cancer: a potential pitfall of pre-surgical imaging opens in new tab/window