向 2024 年諾貝爾獎得主致敬，免費索取他們的研究成果

生理學或醫學獎得獎者的研究精選

*獲獎文章

Victor Ambros

• The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 打開新的分頁／視窗, Cell (Dec 1993)*

• Heterochronic genes and the temporal control of C. elegans development 打開新的分頁／視窗, Trends in Genetics (April 1994)

• A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans 打開新的分頁／視窗, Cell (April 1989)

• Heterochronic Genes Control Cell Cycle Progress and Developmental Competence of C. elegans Vulva Precursor Cells 打開新的分頁／視窗, Cell (March 1996)

• MicroRNAs and Other Tiny Endogenous RNAs in C. elegans 打開新的分頁／視窗, Current Biology (May 2003)

• The Decapping Scavenger Enzyme DCS-1 Controls MicroRNA Levels in Caenorhabditis elegans 打開新的分頁／視窗, Molecular Cell (April 2013)

• miR-14 Regulates Autophagy during Developmental Cell Death by Targeting ip3-kinase 2 打開新的分頁／視窗, Molecular Cell (Nov 2014)

• microRNAs: Tiny Regulators with Great Potential 打開新的分頁／視窗, Cell (Dec 2021)

• Pheromones and Nutritional Signals Regulate the Developmental Reliance on let-7 Family MicroRNAs in C. elegans 打開新的分頁／視窗, Current Biology (June 2019)

• C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5′ UTR of lin-46 mRNA 打開新的分頁／視窗, Cell Reports (Sept 2021)

• Critical contribution of 3′ non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA 打開新的分頁／視窗, Cell Reports (April 2022)

• A bacterial pathogen induces developmental slowing by high reactive oxygen species and mitochondrial dysfunction in Caenorhabditis elegans 打開新的分頁／視窗, Cell Reports (Oct 2023)

Ambros and Ruvkun

• The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor 打開新的分頁／視窗, Molecular Cell (April 2000)

Gary Ruvkun

• Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans 打開新的分頁／視窗, Cell (Dec 1993)*

• The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors 打開新的分頁／視窗, Cell (Dec 1988)

• The unc-86 gene product couples cell lineage and cell identity in C. elegans 打開新的分頁／視窗, Cell (Nov 1990)

• Computational and Experimental Identification of C. elegans microRNAs 打開新的分頁／視窗, Molecular Cell (May 2003)

• The 20 years it took to recognize the importance of tiny RNAs 打開新的分頁／視窗, Cell (Jan 2004)

• Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways 打開新的分頁／視窗, Cell (Jan 2006)

• Detection of broadly expressed neuronal genes in C. elegans 打開新的分頁／視窗, Developmental Biology (Feb 2007)

• A Whole-Genome RNAi Screen for C. elegans miRNA Pathway Genes 打開新的分頁／視窗, Current Biology (Dec 2007)

• Tiny RNA: Where do we come from? What are we? Where are we going? 打開新的分頁／視窗 Trends in Plant Science (July 2008)

• C. elegans Major Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles 打開新的分頁／視窗, Cell Metabolism (Nov 2009)

• Regulation of the C. elegans molt by pqn-47 打開新的分頁／視窗, Developmental Biology (Dec 2011)

• Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses 打開新的分頁／視窗, Cell (April 2012)

• The Caenorhabditis elegans RDE-10/RDE-11 Complex Regulates RNAi by Promoting Secondary siRNA Amplification 打開新的分頁／視窗, Current Biology (May 2012)

• Pseudomonas aeruginosa Disrupts Caenorhabditis elegans Iron Homeostasis, Causing a Hypoxic Response and Death 打開新的分頁／視窗, Cell Host & Microbe (April 2013)

• piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi Pathway 打開新的分頁／視窗, Developmental Cell (Aug 2015)

• Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression 打開新的分頁／視窗, Cell (April 2019)

• Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes 打開新的分頁／視窗, Cell Metabolism (May 2019)

• Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism 打開新的分頁／視窗, Cell (Feb 2024)

• CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene 打開新的分頁／視窗, Current Biology (June 2024)

物理學獎得主的研究精選

John J Hopfield

• On electron transfer 打開新的分頁／視窗, Biophysical Journal (Oct 1976)

• Photo-induced charge transfer. A critical test of the mechanism and range of biological electron transfer processes 打開新的分頁／視窗, Biophysical Journal (June 1977)

• Hemoglobin-carbon monoxide binding rate. Low temperature magneto-optical detection of spin-tunneling 打開新的分頁／視窗, Biophysical Journal (August 1981)

• Simple Networks for Spike-Timing-Based Computation, with Application to Olfactory Processing 打開新的分頁／視窗, Neuron (March 2003)

• Separating objects and ‘neural’ computation | Séparation des objets et calcul neuronal 打開新的分頁／視窗, Comptes Rendus Biologies (Feb 2003)

Geoffrey E Hinton

• Scene-based and viewer-centered representations for comparing shapes 打開新的分頁／視窗, Cognition (Oct 1988)

• Connectionist learning procedures 打開新的分頁／視窗, Artificial Intelligence (Sept 1989)

• A time-delay neural network architecture for isolated word recognition 打開新的分頁／視窗, Neural Networks (1990)

• Mapping part-whole hierarchies into connectionist networks 打開新的分頁／視窗, Artificial Intelligence (Nov 1990)

• Varieties of Helmholtz Machine 打開新的分頁／視窗, Neural Networks (Nov 1996)

• Learning multiple layers of representation 打開新的分頁／視窗, Trends in Cognitive Science (Oct 2007)

• Learning symmetry groups with hidden units: Beyond the perceptron 打開新的分頁／視窗, Physica D: Nonlinear Phenomena (1986)

化學獎得主的研究精選

David Baker

• Preclinical proof of principle for orally delivered Th17 antagonist miniproteins 打開新的分頁／視窗, Cell (August 2024)

• Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies 打開新的分頁／視窗, Cell (July 2024)

• Computational Design of Cyclic Peptide Inhibitors of a Bacterial Membrane Lipoprotein Peptidase 打開新的分頁／視窗, ACS Chemical Biology (May 2024)

• Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells 打開新的分頁／視窗, Cell (Oct 2023)

• Accurate de novo design of membrane-traversing macrocycles 打開新的分頁／視窗, Cell (Sept 2022)

• A General Computational Approach for Repeat Protein Design 打開新的分頁／視窗, Journal of Molecular Biology (Jan 2015)

• A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells 打開新的分頁／視窗, Cell (July 2014)

• High-Resolution Comparative Modeling with RosettaCM 打開新的分頁／視窗, Structure (Oct 2013)

• Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution 打開新的分頁／視窗, Cell (April 2012)

• Alternate States of Proteins Revealed by Detailed Energy Landscape Mapping 打開新的分頁／視窗, Journal of Molecular Biology (Jan 2011)

• A Double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam Isoforms 打開新的分頁／視窗, Cell (Sept 2008)

• A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains 打開新的分頁／視窗, Cell (Sept 2007)

• The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection 打開新的分頁／視窗, Cell (Feb 2007)

• An Orientation-dependent Hydrogen Bonding Potential Improves Prediction of Specificity and Structure for Proteins and Protein–Protein Complexes 打開新的分頁／視窗, Journal of Molecular Biology (Feb 2003)

Demis Hassabis

• Big-Loop Recurrence within the Hippocampal System Supports Integration of Information across Episodes 打開新的分頁／視窗, Neuron (Sept 2018)

• Reinforcement Learning, Fast and Slow 打開新的分頁／視窗, Trends in Cognitive Sciences (May 2019)

• Neuroscience-Inspired Artificial Intelligence 打開新的分頁／視窗, Neuron (July 2017)

• The Future of Memory: Remembering, Imagining, and the Brain 打開新的分頁／視窗, Neuron (Nov 2012)

John M Jumper

• Upside: Protein Folding in CPU-Hours with Applications to Force-Unfolding of Membrane Proteins 打開新的分頁／視窗, Biophysical Journal (Feb 2020)

• On the Interpretation of Force-Induced Unfolding Studies of Membrane Proteins Using Fast Simulations 打開新的分頁／視窗, Biophysical Journal (Oct 2019)

• A Membrane Burial Potential with H-Bonds and Applications to Curved Membranes and Fast Simulations 打開新的分頁／視窗, Biophysical Journal (Nov 2018)

Selected research by Economics Laureates

Daron Acemoglu

• Optimal adaptive testing for epidemic control: Combining molecular and serology tests 打開新的分頁／視窗, Automatica (February 2024)

• Mirage on the horizon: Geoengineering and carbon taxation without commitment 打開新的分頁／視窗, Journal of Public Economics (March 2023)

• The rise of age-friendly jobs 打開新的分頁／視窗, The Journal of the Economics of Ageing (October 2022)

• The political agenda effect and state centralization 打開新的分頁／視窗, Journal of Comparative Economics (December 2020)

• Innovation by entrants and incumbents 打開新的分頁／視窗, Journal of Economic Theory (May 2015)

• Introduction to economic growth 打開新的分頁／視窗, Journal of Economic Theory (March 2012)

• Markets versus governments 打開新的分頁／視窗, Journal of Monetary Economics (January 2008)

• Politics and economics in weak and strong states 打開新的分頁／視窗, Journal of Monetary Economics (October 2005)

Daron Acemoglu and Simon Johnson

• The value of connections in turbulent times: Evidence from the United States 打開新的分頁／視窗, Journal of Financial Economics (August 2016)

Simon Johnson

• Design and implementation of the price cap on Russian oil exports 打開新的分頁／視窗, Journal of Comparative Economics (December 2023)

• Is newer better? Penn World Table Revisions and their impact on growth estimates 打開新的分頁／視窗, Journal of Monetary Economics (March 2013)

  Propping and tunneling 打開新的分頁／視窗, Journal of Comparative Economics 打開新的分頁／視窗 (December 2003)

  Dodging the grabbing hand: the determinants of unofficial activity in 69 countries 打開新的分頁／視窗, Journal of Public Economics (June 2000)

  Why do firms hide? Bribes and unofficial activity after communism 打開新的分頁／視窗, Journal of Public Economics (June 2000)

James A Robinson with Daron Acemoglu and Simon Johnson

• Chapter 6 Institutions as a Fundamental Cause of Long-Run Growth 打開新的分頁／視窗, Handbook of Economic Growth (2005)