CAS article collection: Chemistry Advancing Health
Highlighting high quality research
Introduction
In the 21st century, with the aim and scope of protecting and improving human health, global scientists including chemists, biologists and physicists are devoted to understanding the basis of diseases, such as malignant tumors, metabolic disorders and Alzheimer’s disease (AD), and to develop novel drugs and diagnostic methods for a better treatment of patients. Chinese Academy of Science (CAS) is one of the leading research institutes in China and scientists from CAS are working at the forefront of chemistry and life science. Here, we would like to present a special article collection highlighting the latest contributions devoted by these scientists from CAS.
With thanks to the Article Selection Editor
Hong Liu is a professor at Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS), and the vice director of State Key Laboratory of Drug Research at SIMM.
Her research efforts are mainly dedicated to researching pharmaceutical chemistry and drug design & discovery. She also focuses on the development of novel organic synthetic methodologies and building focused combinatorial libraries. Dr. Hong Liu has published 310 academic papers in peer-reviewed journals, including Chemical Reviews, Angewandte Chemie International Edition, Journal of Medicinal Chemistry, Chemical Communication, Green Chemistry, Advanced Synthesis & Catalysis, Organic Letters and Journal of Organic Chemistry. Liu has written 12 books as chapter author and applied 56 patents.
She also serves as the associate editor of Bioorganic & Medicinal Chemistry Letters.
Professor Hong Liu
Drug Design and Discovery
Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors 打開新的分頁／視窗 Cui, G., Jin, J., Chen, H., Cao, R., Chen, X., & Xu, B. Bioorganic & Medicinal Chemistry
Design and synthesis of novel C14-urea-tetrandrine derivatives with potent anti-cancer activity 打開新的分頁／視窗 Lan, J., Huang, L., Lou, H., Chen, C., Liu, T., Hu, S., Yao, Y., Song, J-r., Luo, J., Liu, Y-z.,Xia, B., Xia, L., Zeng, X-y-z., David, Y-B., Pan, W. European Journal of Medicinal Chemistry
Liu, X., Zhang, Y., Huang, W., Tan, W., & Zhang, A. Bioorganic & Medicinal Chemistry
Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors 打開新的分頁／視窗 Wei, M. M., Xia, P., Xing, L., Dai, Y., Huang, R. -M., Geng, M. -Y., Zhang, A., Ai, J., Song, Z. -L. European Journal of Medicinal Chemistry
Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors 打開新的分頁／視窗 Yuan, H. -L., Liu, Q. -F., Zhang, L., Hu, S. -H., Chen, T. -T., Li, H. -F., Chen, Y. -D., Xu, Y. C., Lu, T. European Journal of Medicinal Chemistry
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents 打開新的分頁／視窗 Zhou, P., Liang, Y., Zhang, H., Jiang, H., Feng, K., Xu, P., Wang, J., Wang, X., Ding, K., Luo, C., Liu, M., Wang, Y. European Journal of Medicinal Chemistry
Long, L., Luo, Y., Hou, Z. -J., Ma, H. -J., Long, Z. -J., Tu, Z. -C., Huang, L. -J., Liu, Q. -T., Lu, G. European Journal of Medicinal Chemistry
Selective recognition of HIV RNA by dinuclear metallic ligands 打開新的分頁／視窗
Li, X., Chen, B., Lan, L., Wang, R., Luo, D., Liu, L., Cheng, L. Chinese Chemical Letters
Liu, X., Chen, P., Li, X., Ba, M., Jiao, X., Guo, Y., Xie, P. Bioorganic & Medicinal Chemistry
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease 打開新的分頁／視窗 Xu, Y.-X., Wang, H., Li, X.-K., Dong, S.-N., Liu, W.-W., Gong, Q., Wang, T.-D., Tang, Y., Zhu, J., Li, J., Zhang, H.-Y., Mao, F. European Journal of Medicinal Chemistry
Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno[3’,2’:3,4]pyrido[1,2-b]isoquinoline and 5,8,12,12a-tetrahydro-6H-thieno[2’,3’:4,5]pyrido[2,1-a]isoquinoline derivatives as cellular activators of adenosine 5’-monophosphateactivated protein kinase (AMPK) 打開新的分頁／視窗 Gu, Z.-N., Wu, L.-Y., Duan, Y.-N., Wang, J., Zhou, S.-B., Li, J.-Y., Chen, K.-X., Li, J., Liu, H. Bioorganic & Medicinal Chemistry
Precise structures of fucosylated glycosaminoglycan and its oligosaccharides as novel intrinsic factor Xase inhibitors 打開新的分頁／視窗 Shang, F. -N., Gao, N., Yin, R. -H., Lin L. -S., Xiao, C., Zhou, L. -T., Li, Z., Purcell, S. -W., Wu, M. -Y., Zhao, J. -H. European Journal of Medicinal Chemistry
Bioactive Natural Products
Phytochemical variation among the traditional Chinese medicine Mu Dan Pi from Paeonia suffruticosa (tree peony) 打開新的分頁／視窗 Li, S.-S., Wu, Q., Yin, D.-D., Feng, C.-Y., Liu, Z.-A., Wang, L.-S. Phytochemistry
Grayanane diterpenoids with diverse bioactivities from the roots of Pieris formosa 打開新的分頁／視窗 Niu, C.-S., Li, Y., Liu, Y.-B., Ma, S.-G., Liu, F., Cui, L., Yu, H.-B., Wang, X.-J., Qu, J., Yu, S.-S. Tetrahedron
Novel tetrahydrofuran derivatives from Trigonostemon howii with their potential anti-HIV-1 activities 打開新的分頁／視窗 Liu, Y.-P., Zhao, W.-H., Feng, X.-Y., Zhang, Z.-J., Zong, K., Sun, Z.-G., Zheng, Y.-T., Fu, Y.-H. Bioorganic Chemistry
Jatrophane diterpenoids from Euphorbia sororia as potent modulators against P-glycoprotein-based multidrug resistance 打開新的分頁／視窗 Hu, R., Gao, J., Rozimamat, R., & Aisa, H. A. European Journal of Medicinal Chemistry
Borrelidins F–I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89 打開新的分頁／視窗 Sun, J. -B., Shao, J. -L., Sun C. -L., Song, Y. -X., Li, Q. -L., Lu, L. -C., Hu, Y. -F., Gui, C., Zhang, H., Ju, J. -H. Bioorganic & Medicinal Chemistry
Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2 打開新的分頁／視窗 Weng, Z.-M., Ge, G.-B., Dou, T.-Y., Wang, P., Liu, P.-K., Tian, X.-H., Qiao, N., Yu, Y., Zou, L.-W., Zhou, Q., Zhang, W.-D., Hou, J. Bioorganic Chemistry
Pharmaceutical Metabolism
Yang, S., Liu, H., Huang, X., Zhan, L., Luo, P., Xue, J., Chen, R., Nie, Z. International Journal of Mass Spectrometry
Identification of chemicals and rat metabolites of Biqi capsule by liquid chromatography-tandem mass spectrometry following a network pharmacological analysis 打開新的分頁／視窗 Zheng, H., Wang, Z., Liu, W., Ren, T., Zhang, J. International Journal of Mass Spectrometry
New Approaches for Disease Diagnosis
Label-free glucose biosensor based on enzymatic graphene oxide-functionalized tilted fiber grating 打開新的分頁／視窗 Jiang, B., Zhou, K., Wang, C., Sun, Q., Yin, G., Tai, Z., Wilson, K., Zhao, J., Zhang, L. Sensors and Actuators, B: Chemical
Sorting of tumour cells in a microfluidic device by multi-stage surface acoustic waves 打開新的分頁／視窗
Wang, K., Zhou, W., Lin, Z., Cai, F., Li, F., Wu, J., Meng, L., Niu, L., Zheng, H. Sensors and Actuators, B: Chemical
An electrochemical approach capable of prostate specific antigen assay in human serum based on exonuclease-aided target recycling amplification 打開新的分頁／視窗 Miao, P., Jiang, Y., Wang, Y., Yin, J., Tang, Y. Sensors and Actuators, B: Chemical
Sun, X., Li, B., Tian, C., Yu, F., Zhou, N., Zhan, Y., Chen, L. Analytica Chimica Acta
Chemical Probes in Medical Research
Biomarker-targeted fluorescent probes for breast cancer imaging (Review article) 打開新的分頁／視窗 Yue, D., Wang, M., Deng, F., Yin, W., Zhao, H., Zhao, X., Xu, Z. Chinese Chemical Letters
Xiong, H., Han, J., Wang, J., Lu, W. -C., Wang, C., Chen, Y., Lian, F. -L., Zhang, N. -X., Liu, Y. -C., Zhang, C. -H., Ding, H., Jiang, H. -L., Lu, W. -C., Luo, C., Zhou, B. European Journal of Medicinal Chemistry
New Analytical Techniques for Food Safety
Utilization of a lateral flow colloidal gold immunoassay strip based on surface-enhanced Raman spectroscopy for ultrasensitive detection of antibiotics in milk 打開新的分頁／視窗 Shi, Q., Huang, J., Sun, Y., Yin, M., Hu, M., Hu, X., Zhang, Z., Zhang, G. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Quantitative structure-retention relationships model for retention time prediction of veterinary drugs in food matrixes 打開新的分頁／視窗 Noreldeen, H.A.A., Liu, X., Wang, X., Fu, Y., Li, Z., Lu, X., Zhao, C., Xu, G. International Journal of Mass Spectrometry
New Analytical Techniques for Biomedical Research
Qu, F., Chen, Z., You, J., Song, C. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO 打開新的分頁／視窗
Gu, Y., Lin, D., Tang, Y., Fei, X., Wang, C., Zhang, B., Zhou, J. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Coumarin/fluorescein-fused fluorescent dyes for rapidly monitoring mitochondrial pH changes in living cells 打開新的分頁／視窗 Qi, S., Li, Q., Liu, W., Ren, H., Zhang, H., Wu, J., Ge, J., Wang, P. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Mass spectrometry imaging of intact cholesterol in a mouse esophagus tissue section and mouse zygotes using VUV laser desorption/ionization method 打開新的分頁／視窗 Wang, J., Wang, Z., Liu, F., Mo, Y., Cai, L., Sun, C., Zhang, S., Zhang, R., Abliz, Z., Zhang, X. International Journal of Mass Spectrometry
Zhao, N.-N., Sun, Y.-F., Zong, L., Liu, S., Song, F.-R., Liu, Z.-Q., Liu, S.-Y. International Journal of Mass Spectrometry
Association of alteration of nucleosides and nucleotides with gastric cancer microenvironment 打開新的分頁／視窗 Guo, S., Wang, Y., Zhou, D., Xu, Y., Chen, T., Li, Z. International Journal of Mass Spectrometry
Biosensors and Bioelectronics
Carbon dots based photoelectrochemical sensors for ultrasensitive detection of glutathione and its applications in probing of myocardial infarction 打開新的分頁／視窗 Li, Z., Zhang, J., Li, Y., Zhao, S., Zhang, P., Zhang, Y., Bi, J., Liu, G., Yue, Z. Biosensors and Bioelectronics
Lipopolysaccharides detection on a grating-coupled surface plasmon resonance smartphone biosensor 打開新的分頁／視窗 Zhang, J., Khan, I., Zhang, Q., Liu, X., Dostalek, J., Liedberg, B., Wang, Y. Biosensors and Bioelectronics
Electrochemical integrated paper-based immunosensor modified with multi-walled carbon nanotubes nanocomposites for point-of-care testing of 17β-estradiol 打開新的分頁／視窗 Wang, Y., Luo, J., Liu, J., Li, X., Kong, Z., Jin, H., Cai, X. Biosensors and Bioelectronics
Lin, S., Feng, W., Miao, X., Zhang, X., Chen, S., Chen, Y., Wang, W., Zhang, Y. Biosensors and Bioelectronics
Robust hybrid enzyme nanoreactor mediated plasmonic sensing strategy for ultrasensitive screening of anti-diabetic drug 打開新的分頁／視窗 Kong, W., Wu, D., Hu, N., Li, N., Dai, C., Chen, X., Suo, Y., Li, G., Wu, Y. Biosensors and Bioelectronics
Metabolomics Data Analysis
Comprehensive evaluation of untargeted metabolomics data processing software in feature detection, quantification and discriminating marker selection 打開新的分頁／視窗 Li, Z., Lu, Y., Guo, Y., Cao, H., Wang, Q., Shui, W. Analytica Chimica Acta