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Dennis Discher

DD

Dennis Discher

Title: Mechanoregulation of cancer mutations &Macrophage clusters durably eliminate cohesive tumors

University of Pennsylvania, USA

The Discher lab has sought to discover, explain, and exploit the mechanobiology of cells, molecules, and tissues. Early discoveries included matrix elasticity effects on stem cell differentiation (Cell 2006) and mechanoregulation of the nucleus (Science 2013). Current efforts focus on physics-driven evolution of mutations (Cell 2016) and tumoricidal macrophages (Nat BME 2023) informed by molecular studies of ‘foreign’ versus ‘self’ (Science 2013). Trainees from the lab are leaders in academia and industry around the world, and honors include election to the US National Academy of Medicine, and the US National Academy of Engineering. Service includes Editorial Boards of Science and PNAS Nexus among other journals.